Raja Joel M, Maturana Miguel A, Kayali Sharif, Khouzam Amir, Efeovbokhan Nephertiti
Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38119, United States.
Department of Cardiology, NEA Baptist Jonesboro, Jonesboro, AR 72401, United States.
World J Clin Cases. 2023 Mar 16;11(8):1684-1693. doi: 10.12998/wjcc.v11.i8.1684.
Diabetic foot ulcer (DFU) is a debilitating and severe manifestation of uncontrolled and prolonged diabetes that presents as ulceration, usually located on the plantar aspect of the foot. Approximately 15% of individuals with diabetes will eventually develop DFU, and 14%-24% of them will require amputation of the ulcerated foot due to bone infection or other ulcer-related complications. The pathologic mechanisms underlying DFU are comprise a triad: Neuropathy, vascular insufficiency, and secondary infection due to trauma of the foot. Standard local and invasive care along with novel approaches like stem cell therapy pave the way to reduce morbidity, decrease amputations, and prevent mortality from DFU. In this manuscript, we review the current literature with focus on the pathophysiology, preventive options, and definitive management of DFU.
糖尿病足溃疡（DFU）是未得到控制的长期糖尿病的一种使人衰弱的严重表现，通常表现为足部溃疡，多位于足底。约15%的糖尿病患者最终会发生DFU，其中14%-24%的患者会因骨感染或其他与溃疡相关的并发症而需要截肢溃疡足。DFU的病理机制包括三个方面：神经病变、血管功能不全以及足部创伤引起的继发性感染。标准的局部和侵入性治疗以及干细胞治疗等新方法为降低DFU的发病率、减少截肢和预防死亡铺平了道路。在本手稿中，我们回顾了当前的文献，重点关注DFU的病理生理学、预防措施和确定性治疗。
