Institute for Electric Light Sources, Fudan University, Shanghai 200433, China.
Academy for Engineering and Technology, Fudan University, Shanghai 200433, China.
J Mater Chem B. 2024 Nov 13;12(44):11347-11358. doi: 10.1039/d4tb01349b.
The ionic environment has a strong influence on the bioelectricity of skin, which is also present in the wound healing process. Inspired by this, we proposed a mechanism for hydrogel-based dressings to respond to endogenous electric fields through exudate absorption and conducted a verification study using a typical hydrogel, namely, polyacrylamide and sodium alginate (PAM-SA) hydrogels, as an example. Theoretical calculations showed that the PAM-SA hydrogels could absorb and orient the various electrolytes of exudate in the hydrogel at the wound site, contributing to the reconstruction of the electric field at the wound site. During the treatment process, this effect significantly accelerated the healing process of the rat epidermis, which exceeded the conventional dressing in terms of healing speed and efficacy, and the wounds on the complete layer of rat skin (wound area: 1.13 cm) could be rapidly repaired within 10 days. Revealing the electrophysiological behavior of PAM-SA dressings during wound healing can help further improve the design model, the optimization concept, and development paths for the bioelectrical structures of modern dressings and bioelectrical stimulation in wound healing.
离子环境对皮肤的生物电学有很强的影响，这种影响也存在于伤口愈合过程中。受此启发，我们提出了一种水凝胶敷料通过吸收渗出液来响应内源性电场的机制，并以典型的水凝胶，即聚丙烯酰胺和海藻酸钠（PAM-SA）水凝胶为例进行了验证研究。理论计算表明，PAM-SA 水凝胶可以吸收并使伤口部位的渗出液中的各种电解质定向排列，有助于在伤口部位重建电场。在治疗过程中，这种效果显著加快了大鼠表皮的愈合过程，在愈合速度和效果方面超过了传统敷料，大鼠完整皮肤层上的伤口（伤口面积：1.13cm）可以在 10 天内迅速修复。揭示 PAM-SA 敷料在伤口愈合过程中的电生理行为有助于进一步改进现代敷料的生物电结构和伤口愈合中的电刺激的设计模型、优化理念和开发路径。
