Wu Chenwei, Liu Bo, Wen Qiulan, Zhai Qiliang
Department of Urology, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, Jiangxi, 341000, China.
Department of Burns and Plastics Surgery, Liuzhou Worker's Hospital, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, 545000, China.
Mater Today Bio. 2025 Apr 12;32:101769. doi: 10.1016/j.mtbio.2025.101769. eCollection 2025 Jun.
Wound healing in patients with diabetes is challenging because of chronic inflammation, inadequate vascularization, and susceptibility to infection. Current wound dressings often target specific stages of healing and lack comprehensive therapeutic approaches. This study introduces a novel approach using a photodetachable sponge scaffold incorporating carbon nanotubes (CNTs), known for their high photothermal conversion efficiency, electrical conductivity, and water absorption properties. The scaffold incorporated pyrrolidonecarboxylic acid zinc (PCZ), a compound with anti-inflammatory and moisturizing properties, which was cross-linked within a network of CNTs and a decellularized dermal matrix. The resulting shape-memory sponge scaffold actively interfaces with endogenous electric fields, facilitating electrical signal transmission to skin cells and accelerating tissue repair. Upon exposure to near-infrared (NIR) light, the PCZ scaffold enhanced antibacterial efficacy (98 %) through photothermal conversion, promoting tissue metabolism at the wound site. Notably, the scaffold absorbed wound exudates and gradually released Zn, effectively reducing chronic inflammation in the mice. In a diabetic rat wound model, the PCZ scaffold absorbed exudates, reduced inflammation, and accelerated granulation tissue formation, wound angiogenesis, and re-epithelialization. This innovative PCZ sponge dressing shows promise for enhancing the healing of diabetic wounds.
由于存在慢性炎症、血管化不足以及易感染等问题，糖尿病患者的伤口愈合具有挑战性。当前的伤口敷料通常针对愈合的特定阶段，缺乏全面的治疗方法。本研究引入了一种新颖的方法，即使用一种结合了碳纳米管（CNTs）的光可分离海绵支架，碳纳米管以其高光热转换效率、导电性和吸水性而闻名。该支架掺入了吡咯烷酮羧酸锌（PCZ），一种具有抗炎和保湿特性的化合物，它在碳纳米管和脱细胞真皮基质的网络中交联。由此产生的形状记忆海绵支架与内源性电场积极相互作用，促进电信号向皮肤细胞的传递并加速组织修复。在近红外（NIR）光照射下，PCZ支架通过光热转换提高了抗菌效果（98%），促进了伤口部位的组织代谢。值得注意的是，该支架吸收伤口渗出液并逐渐释放锌，有效减轻了小鼠的慢性炎症。在糖尿病大鼠伤口模型中，PCZ支架吸收渗出液、减轻炎症，并加速肉芽组织形成、伤口血管生成和再上皮化。这种创新的PCZ海绵敷料在促进糖尿病伤口愈合方面显示出前景。
