Sarıkaya Buse, Kolay Ezgi, Guney-Coskun Merve, Yiğit-Ziolkowski Aslı, Aktaç Şule
Department of Nutrition and Dietetics, Faculty of Health Sciences, Amasya University, Amasya 05100, Turkey.
Dietitian, Independent Nutrition Reseacher, Istanbul 34000, Turkey.
Nutr Rev. 2025 Jun 1;83(6):1083-1098. doi: 10.1093/nutrit/nuae143.
Consuming antioxidant-rich foods has been associated with potential benefits in managing chronic diseases by reducing oxidative stress and inflammation.
This systematic review aimed to evaluate the effects of Aronia melanocarpa (aronia berry or chokeberry) on human inflammation biomarkers and antioxidant enzymes.
A systematic search was conducted across multiple databases, including PubMed, Scopus, Science Direct, and Web of Science, to identify relevant studies investigating the potential effects of aronia on human inflammation biomarkers and antioxidant enzymes between April 2022 and November 2023.
The selection of studies followed the PRISMA guidelines, data screening was conducted by 4 independent reviewers, and data extraction and risk-of-bias assessments were performed by 2 independent reviewers using the Cochrane Risk of Bias 2 tool.
A total of 1986 studies were screened, and 18 studies that met the inclusion criteria were included in a systematic review that investigated the anti-inflammatory effects of aronia on various health parameters. These studies primarily focused on the effects of aronia on cardiometabolic diseases, performance in sport, and other health parameters.
This study examined the effects of Aronia intervention on human health outcomes using aronia juice, extract, or oven-dried powder for a period of 4 to 13 weeks. The primary health parameters considered were C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-1ß (IL-1ß), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione peroxidase (GSH-Px). The results showed that aronia had a beneficial effect on several inflammatory cytokines, including reductions in CRP, TNF-α and IL-6 concentrations, as well as elevated IL-10 levels. Moreover, positive changes have been observed in antioxidant enzyme systems, including; elevated SOD, GSH-Px and CAT activity. The findings of the presented studies provide evidence that Aronia melanocarpa may have beneficial effects on inflammatory markers.
PROSPERO registration No. CRD42022325633.
食用富含抗氧化剂的食物通过减轻氧化应激和炎症，对慢性病管理具有潜在益处。
本系统评价旨在评估黑果腺肋花楸（黑果花楸或野樱莓）对人体炎症生物标志物和抗氧化酶的影响。
在多个数据库中进行了系统检索，包括PubMed、Scopus、Science Direct和Web of Science，以识别2022年4月至2023年11月期间研究黑果花楸对人体炎症生物标志物和抗氧化酶潜在影响的相关研究。
研究选择遵循PRISMA指南，由4名独立评审员进行数据筛选，2名独立评审员使用Cochrane偏倚风险2工具进行数据提取和偏倚风险评估。
共筛选了1986项研究，18项符合纳入标准的研究被纳入一项系统评价，该评价调查了黑果花楸对各种健康参数的抗炎作用。这些研究主要关注黑果花楸对心血管代谢疾病、运动表现和其他健康参数的影响。
本研究使用黑果花楸汁、提取物或烘干粉末，对人体健康结局进行了为期4至13周的干预。所考虑的主要健康参数为C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）、白细胞介素-1β（IL-1β）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和还原型谷胱甘肽过氧化物酶（GSH-Px）。结果表明，黑果花楸对多种炎性细胞因子有有益作用，包括降低CRP、TNF-α和IL-6浓度，以及提高IL-10水平。此外，在抗氧化酶系统中也观察到了积极变化，包括SOD、GSH-Px和CAT活性升高。本研究结果提供了证据，表明黑果腺肋花楸可能对炎症标志物有有益作用。
PROSPERO注册号CRD42022325633。
