设计小分子和大分子传感器用于成像氧化还原活性过渡金属信号。
Designing small-molecule and macromolecule sensors for imaging redox-active transition metal signaling.
机构信息
Department of Chemistry, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Department of Chemistry, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
出版信息
Curr Opin Chem Biol. 2024 Dec;83:102541. doi: 10.1016/j.cbpa.2024.102541. Epub 2024 Nov 4.
Transition metals play essential roles in biology, where these nutrients regulate protein activity as active site cofactors or via metalloallostery. In contrast, dysregulation of transition metal homeostasis can lead to unique metal-dependent signaling pathways connected to aging and disease, such as cuproptosis and ferroptosis for copper- and iron-dependent cell death or cuproplasia and ferroplasia for copper- and iron-dependent cell growth and proliferation, respectively. New methods that enable detection of bioavailable transition metal pools with both metal and oxidation state specificity can help decipher their contributions to health and disease. Here we summarize recent advances in designing sensors for imaging transition metals and their applications to uncover new metal biology.
过渡金属在生物学中发挥着重要作用，这些营养物质作为活性位点辅助因子或通过金属变构调节蛋白质活性。相比之下，过渡金属动态平衡的失调可能导致与衰老和疾病相关的独特的金属依赖性信号通路，例如铜依赖性细胞死亡的铜死亡和铁死亡，或铜和铁依赖性细胞生长和增殖的铜形成和铁形成。能够检测具有金属和氧化态特异性的生物可用过渡金属池的新方法可以帮助破译它们对健康和疾病的贡献。在这里，我们总结了设计用于成像过渡金属及其应用的传感器的最新进展，以揭示新的金属生物学。
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