Goffinet A M, Daumerie C, Langerwerf B, Pieau C
J Comp Neurol. 1986 Jan 1;243(1):106-16. doi: 10.1002/cne.902430109.
Histogenesis was studied in forebrain cortical areas of two reptiles, Emys orbicularis and Lacerta trilineata, by using tritiated thymidine autoradiography. Four areas were considered: the dorsomedial, the general (dorsal), and the lateral cortices, and the dorsal ventricular ridge (DVR). The bulk of neurogenesis in these four pallial fields proceeds within a short period of 8-9 days, between developmental stages 15 and 18 in Emys and stages 32-34 in Lacerta. Lateral-to-medial as well as anterior-to-posterior tangential gradients of histogenesis are present in both species. Radial neurogenetic gradients are directed from outside to inside, except in the medial cortex of lizards, where no radial gradient is seen. This pattern of histogenesis in the cortex of turtles and lizards is comparable to that in mammals in terms of timing and tangential, areal variations. It might represent a "common denominator" of cortical histogenesis. However, in contrast to the mammalian cortex, which develops according to an inside to outside, "inverted" pattern, radial neurogenesis in the cortex of turtles and lizards follows an outside-to-inside gradient. These observations suggest that the inside-out gradient of cortical neurogenesis has been acquired during evolution of the synapsid radiation from stem reptiles to mammals, and that it may be related to the development of radial cortical architectonics.
利用氚标记胸腺嘧啶核苷放射自显影技术，对两种爬行动物圆斑水龟（Emys orbicularis）和三线蜥蜴（Lacerta trilineata）前脑皮质区域的组织发生进行了研究。研究考虑了四个区域：背内侧皮质、一般（背侧）皮质、外侧皮质以及背侧室嵴（DVR）。在这四个脑皮层区域，大部分神经发生在短时间内进行，即圆斑水龟发育阶段15至18之间以及三线蜥蜴发育阶段32至34之间的8 - 9天内。两个物种均存在从外侧到内侧以及从前向后的组织发生切线梯度。径向神经发生梯度是从外向内，不过蜥蜴的内侧皮质除外，在该区域未观察到径向梯度。龟类和蜥蜴皮质的这种组织发生模式在时间以及切线、区域变化方面与哺乳动物的类似。它可能代表了皮质组织发生的“共同特征”。然而，与按照从内向外的“反转”模式发育的哺乳动物皮质不同，龟类和蜥蜴皮质中的径向神经发生遵循从外向内的梯度。这些观察结果表明，皮质神经发生的由内向外梯度是在从原始爬行动物到哺乳动物的合弓纲辐射演化过程中获得的，并且它可能与径向皮质结构的发育有关。
