Reeß Lukas G, Salih Hadi, Delikaya Murat, Paul Friedemann, Oertel Frederike Cosima
Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
Neurol Ther. 2025 Feb;14(1):45-56. doi: 10.1007/s40120-024-00670-1. Epub 2024 Nov 5.
Optical coherence tomography angiography (OCT-A) is a state-of-the-art imaging technique for the retinal vasculature to accurately segment the capillary network and assign it to retinal layers. OCT-A is a promising technique to better understand neurological diseases with visual system manifestations, such as multiple sclerosis (MS), and to identify and characterize vascular biomarkers. Initial studies suggested vascular changes in MS and its differential diagnoses such as myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and neuromyelitis optica spectrum disorder (NMOSD). Here we review clinical and technical aspects of OCT-A imaging and discuss the potential for the MS field as well as barriers that need to be overcome before OCT-A can be established in clinical application.
光学相干断层扫描血管造影（OCT-A）是一种用于视网膜血管系统的先进成像技术，可精确分割毛细血管网络并将其分配到视网膜各层。OCT-A是一种很有前景的技术，有助于更好地理解具有视觉系统表现的神经系统疾病，如多发性硬化症（MS），并识别和表征血管生物标志物。初步研究表明MS及其鉴别诊断疾病，如髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）和视神经脊髓炎谱系障碍（NMOSD）存在血管变化。在此，我们综述了OCT-A成像的临床和技术方面，并讨论了其在MS领域的潜力以及在OCT-A能够在临床应用中确立之前需要克服的障碍。
