Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 LanXi Road, Shanghai, 200062, China.
Department of Public Health, College of Health Professions, Marshall University, West Virginia, USA.
BMC Endocr Disord. 2024 Nov 6;24(1):236. doi: 10.1186/s12902-024-01768-1.
Branched-chain amino acid (BCAA) has been reported to be associated with obesity, the association of BCAA with visceral fat area (VFA) and subcutaneous fat area (SFA) remained unclear in patients with type 2 diabetes.
This cross-sectional study was conducted in 284 patients with type 2 diabetes mellitus. Enzyme-linked immunospecific assay was used to measure levels of serum BCAA and branched-chain keto acid (BCKA). VFA and SFA were measured with bio-impedance analysis method. The association between BCAA and VFA was calculated using Pearson correlation and multivariable linear regression analysis.
There were significant differences in the means of body mass index, waist circumstance, SFA and VFA among the three groups divided by total BCAA tertiles (all p < 0.05). Compared to patients with lower levels of serum BCAA (the lower tertile group), the means of VFA and SFA were significantly larger in the middle and upper tertile groups (all p < 0.05). However, the differences in above obesity parameters were nonsignificant according to various BCKA tertiles. Pearson correlation analysis also demonstrated that BCAA levels were positive associated with each obesity parameter (p < 0.05). Nevertheless, multivariable linear regression analysis showed that levels of serum BCAA were correlated with VFA, BMI and WC (all p < 0.05) rather than SFA after adjusted for other confounders.
levels of serum BCAA were more closely correlated with VFA than SFA, prospective studies should be warranted to further explore the mechanism mediating BCAA and visceral fat accumulation in Human beings.
Not applicable.
支链氨基酸（BCAA）已被报道与肥胖有关，但在 2 型糖尿病患者中，BCAA 与内脏脂肪面积（VFA）和皮下脂肪面积（SFA）的关系尚不清楚。
本横断面研究纳入了 284 例 2 型糖尿病患者。采用酶联免疫吸附法测定血清 BCAA 和支链酮酸（BCKA）水平。采用生物电阻抗分析法测量 VFA 和 SFA。采用 Pearson 相关和多元线性回归分析计算 BCAA 与 VFA 之间的相关性。
根据总 BCAA 三分位数将患者分为三组，三组间的体质指数、腰围、SFA 和 VFA 均值均存在显著差异（均 P<0.05）。与血清 BCAA 水平较低的患者（低三分位组）相比，中三分位组和高三分位组的 VFA 和 SFA 均值显著增大（均 P<0.05）。然而，根据不同的 BCKA 三分位数，上述肥胖参数的差异无统计学意义。Pearson 相关分析也表明，BCAA 水平与各肥胖参数呈正相关（P<0.05）。然而，多元线性回归分析显示，在校正其他混杂因素后，血清 BCAA 水平与 VFA、BMI 和 WC 相关（均 P<0.05），而与 SFA 不相关。
血清 BCAA 水平与 VFA 的相关性强于 SFA，需要进行前瞻性研究以进一步探讨介导 BCAA 和内脏脂肪堆积的机制。
无。
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