Department of Surgery, Division of Surgical Oncology, University of California Davis, Sacramento, California, USA.
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
J Surg Oncol. 2024 Sep;130(3):543-551. doi: 10.1002/jso.27751. Epub 2024 Jun 21.
Soft tissue sarcomas (STS) are a heterogenous group of malignancies of mesenchymal origin. Given recent data linking obesity as well as the pattern of fat distribution with cancer outcomes, we sought to investigate the association of visceral fat area (VFA) and subcutaneous fat area (SFA) with oncologic outcomes in patients with STS undergoing surgery.
We analyzed data from 88 patients with STS diagnosed from 2008 to 2022. Predictor variables included body mass index (BMI), VFA, and SFA. VFA and SFA were obtained from computed tomography of the abdomen and pelvis. Univariable and multivariable Cox regression analysis was used to analyze associations between predictor variables and overall survival and recurrence-free survival.
Although BMI was closely correlated with VFA (r = 0.69, p < 0.0001) and SFA (r = 0.80, p < 0.0001), there was no significant association between high BMI, VFA or SFA, and worse oncologic outcomes.
Although VFA and SFA are strongly correlated with BMI, we did not observe BMI nor imaging metrics of fat composition to be associated with worse oncologic outcomes. Further research is needed to elucidate any links between body fat content and metabolic or immune factors governing oncologic outcomes in STS.
软组织肉瘤（STS）是一种起源于间叶组织的异质性恶性肿瘤。鉴于最近的数据表明肥胖以及脂肪分布模式与癌症结局有关，我们试图研究内脏脂肪面积（VFA）和皮下脂肪面积（SFA）与接受手术治疗的 STS 患者的肿瘤学结局之间的关系。
我们分析了 2008 年至 2022 年期间诊断为 STS 的 88 名患者的数据。预测变量包括体重指数（BMI）、VFA 和 SFA。VFA 和 SFA 是通过腹部和骨盆的计算机断层扫描获得的。单变量和多变量 Cox 回归分析用于分析预测变量与总生存和无复发生存之间的关系。
尽管 BMI 与 VFA（r=0.69，p<0.0001）和 SFA（r=0.80，p<0.0001）密切相关，但高 BMI、VFA 或 SFA 与较差的肿瘤学结局之间没有显著关联。
尽管 VFA 和 SFA 与 BMI 密切相关，但我们没有观察到 BMI 或脂肪成分的影像学指标与较差的肿瘤学结局相关。需要进一步研究阐明体内脂肪含量与代谢或免疫因素之间的任何联系，这些因素决定了 STS 的肿瘤学结局。
