饮食中的支链氨基酸与菲律宾裔移民女性肥胖的几率：菲律宾女性饮食与健康研究（FiLWHEL）。
Dietary branched-chain amino acids and odds of obesity among immigrant Filipino women: the Filipino women's diet and health study (FiLWHEL).
机构信息
Department of Food and Nutrition, College of Human Ecology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, South Korea.
Research Institute of Human Ecology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, South Korea.
出版信息
BMC Public Health. 2022 Apr 5;22(1):654. doi: 10.1186/s12889-022-12863-0.
BACKGROUND
The dietary environment promoting adiposity keeps evolving and of interest is the significance of dietary branched-chain amino acids (BCAA). This study assessed the association between dietary BCAA intakes and odds of obesity among immigrant Filipino women in Korea.
METHOD
We included 423 immigrant Filipino women enrolled in the Filipino Women's diet and health study in the Republic of Korea. Dietary BCAA intakes were estimated from 24 hour recalls and adjusted for energy intake using the residual method. General obesity was derived from direct anthropometric measurements (height, weight and waist circumference - WC) and defined as body mass index (BMI) ≥25 kg/m and abdominal obesity as WC ≥80 cm. Odds ratios (OR) and 95% confidence intervals (CI) by tertile distribution of energy-adjusted BCAA intakes were estimated using multivariable logistic regression with a two-sided P < 0.05.
RESULTS
Median (interquartile range) for BCAA intakes in g/day were; 7.9 (5.8, 10.3) g/day for total BCAA; 2.0 (1.5, 2.6) g/day for isoleucine, 3.5(2.5, 4.6) g/day for leucine and 2.4 (1.8, 3.1) g/day for valine. Mean BMI and WC were 23.6 ± 3.8 kg/m and 79.8 ± 9.3 cm, respectively. Also, 30.2% (128) had BMI ≥25 kg/m and 42.0% (178) had WC ≥80 cm. ORs (95%CIs) of general obesity across tertile distribution of energy-adjusted total BCAA intakes were 1.00, 0.81 (0.47, 1.37) and 0.62 (0.36, 1.07; P for trend = 0.08). A similar trend was observed across tertile distribution of energy-adjusted isoleucine, leucine and valine intakes. However, there was a statistically significant inverse association between total BCAA intake and odds of general obesity in a subset of non-smokers; 1.00, 0.68 (0.39, 1.20) and 0.55 (0.31, 0.98; P for trend = 0.04).
CONCLUSION
We found a suggestive inverse association between higher dietary BCAA intake and odds of obesity in this sample of immigrant Filipino women, particularly among non-smokers. Prospective cohort studies among the immigrant population will be necessary to verity these findings.
背景
促进肥胖的饮食环境在不断演变，人们对饮食中支链氨基酸（BCAA）的意义很感兴趣。本研究评估了菲律宾移民女性饮食中 BCAA 摄入量与肥胖几率之间的关系。
方法
我们纳入了 423 名在韩国参加菲律宾女性饮食与健康研究的菲律宾移民女性。通过 24 小时回顾法估计 BCAA 摄入量，并使用残差法根据能量摄入进行调整。通过直接人体测量（身高、体重和腰围 - WC）得出普通肥胖，定义为体重指数（BMI）≥25kg/m 和腹部肥胖为 WC≥80cm。采用多变量 logistic 回归估计能量调整后 BCAA 摄入量三分位数分布的比值比（OR）和 95%置信区间（CI），双侧 P<0.05。
结果
BCAA 摄入量的中位数（四分位距）为 g/天；总 BCAA 为 7.9（5.8，10.3）g/天；异亮氨酸为 2.0（1.5，2.6）g/天；亮氨酸为 3.5（2.5，4.6）g/天；缬氨酸为 2.4（1.8，3.1）g/天。平均 BMI 和 WC 分别为 23.6±3.8kg/m 和 79.8±9.3cm，30.2%（128）的 BMI≥25kg/m，42.0%（178）的 WC≥80cm。能量调整后总 BCAA 摄入量三分位数分布的一般肥胖 OR（95%CI）分别为 1.00、0.81（0.47，1.37）和 0.62（0.36，1.07；P 趋势=0.08）。能量调整后的异亮氨酸、亮氨酸和缬氨酸摄入量三分位数分布也呈现出类似的趋势。然而，在非吸烟者亚组中，总 BCAA 摄入量与一般肥胖的几率之间存在统计学上显著的负相关；1.00、0.68（0.39，1.20）和 0.55（0.31，0.98；P 趋势=0.04）。
结论
在本菲律宾移民女性样本中，我们发现较高的饮食 BCAA 摄入量与肥胖几率呈负相关，尤其是在不吸烟者中。有必要在移民人群中开展前瞻性队列研究来验证这些发现。
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