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葡聚糖-透明质酸混合填充剂的临床疗效和安全性概况:病例系列分析

Clinical Outcomes and Safety Profile of a Dextranomer-Hyaluronic Acid Hybrid Filler: A Case Series Analysis.

作者信息

Ruiz Nazaret, Lopez Roberto Miranda, Marques Ruben, Fontenete Silvia

机构信息

Private Clinic, Gijón, Spain.

Hospital Cruz Roja, Gijón, Spain.

出版信息

J Cosmet Dermatol. 2025 Jan;24(1):e16653. doi: 10.1111/jocd.16653. Epub 2024 Nov 6.

DOI:10.1111/jocd.16653
PMID:39502010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11743303/
Abstract

BACKGROUND

The demand for aesthetic treatments targeting the middle and lower face is on the rise, especially because of changes in appearance associated with aging.

AIM

This study aimed to assess the use of a hybrid filler for sculpting and contouring of the chin, jaw, and malar region.

METHODS AND MATERIALS

A retrospective analysis was performed on patients who underwent jaw and chin contouring and cheek augmentation using a hybrid filler (hyaluronic acid and dextranomer). The evaluation focused on the naturalness of appearance, enhancement in volume, and the durability of the results, employing a 5-point scale. Both patient satisfaction and physician evaluations were measured using the Likert scale and the Global Aesthetic Improvement Scale (GAIS), respectively. Follow-up with patients extended up to 6 months after treatment, during which any treatment-related adverse events (AEs) were meticulously recorded and analyzed.

RESULTS

Nineteen patients participated in the study, receiving an average injection volume of 2.4 ± 0.9 mL to attain the desired outcomes. The evaluation of natural appearance, volumizing effects, and durability at the analyzed time point consistently scored above 4. All 19 patients' aesthetic improvement was evaluated as "very much improved" and "much improved", at the GAIS score. All patients report improvement in their appearance, with 89.5% rating it as "very much improved" or "much improved" on the Likert scale. Only expected AEs such as mild pain and lower swelling were registered.

CONCLUSION

The hybrid filler proved effective and safe for facial contouring, with significant patient satisfaction and minimal adverse effects.

摘要

背景

针对中下面部的美容治疗需求不断增加,尤其是由于与衰老相关的外观变化。

目的

本研究旨在评估一种混合填充剂用于雕刻和塑形下巴、下颌及颧部区域的效果。

方法和材料

对使用混合填充剂(透明质酸和葡聚糖微球)进行下颌和下巴塑形以及脸颊填充的患者进行回顾性分析。评估集中在外观的自然度、体积增加情况以及效果的持久性,采用5分制量表。患者满意度和医生评估分别使用李克特量表和全球美学改善量表(GAIS)进行测量。对患者的随访持续至治疗后6个月,在此期间仔细记录并分析任何与治疗相关的不良事件(AE)。

结果

19名患者参与了该研究,平均注射量为2.4±0.9 mL以达到预期效果。在分析时间点对自然外观、体积增加效果和持久性的评估始终得分高于4分。在GAIS评分中,所有19名患者的美学改善被评为“非常显著改善”和“显著改善”。所有患者均报告外观有所改善,在李克特量表上,89.5%的患者将其评为“非常显著改善”或“显著改善”。仅记录到如轻微疼痛和轻度肿胀等预期的不良事件。

结论

混合填充剂在面部塑形方面被证明是有效且安全的,患者满意度高且不良反应最小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/ed2da6fb3e65/JOCD-24-e16653-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/a43d3b0af96d/JOCD-24-e16653-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/c5f19e60c1c8/JOCD-24-e16653-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/47b7e3ac3348/JOCD-24-e16653-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/2831ae752488/JOCD-24-e16653-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/0a4466f1e393/JOCD-24-e16653-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/86cf5830a7a4/JOCD-24-e16653-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/ed2da6fb3e65/JOCD-24-e16653-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/a43d3b0af96d/JOCD-24-e16653-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/c5f19e60c1c8/JOCD-24-e16653-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/47b7e3ac3348/JOCD-24-e16653-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/2831ae752488/JOCD-24-e16653-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/0a4466f1e393/JOCD-24-e16653-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/86cf5830a7a4/JOCD-24-e16653-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11743303/ed2da6fb3e65/JOCD-24-e16653-g006.jpg

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