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[铁死亡:机制及其在肿瘤治疗中的应用]

[Ferroptosis:Mechanisms and Application in Tumor Treatment].

作者信息

Shao Shi-Han, Qiu Shu-Ting, Li Yu, Zhang Ying-Ying, Cao Yue-Jia, DI Chun-Hong, Tan Xiao-Hua

机构信息

School of Public Health,Hangzhou Normal University,Hangzhou 311121,China.

Department of Clinical Laboratory,Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2024 Oct;46(5):732-739. doi: 10.3881/j.issn.1000-503X.15881.

Abstract

Ferroptosis is a form of regulated cell death that depends on iron and reactive oxygen species.Different from apoptosis,necrosis,and autophagy,ferroptosis is characterized by the accumulation of lipid peroxides in cells.Studies have discovered that ferroptosis is closely associated with the occurrence and development of tumors and inducing ferroptosis in tumor cells can enhance the therapeutic effects of drugs on tumors.This article summarizes the latest research progress in ferroptosis regarding its mechanisms and associations with tumors,aiming to provide a reference for further understanding the interaction mechanisms between ferroptosis and tumors and offering new insights and targets for the treatment of tumors.

摘要

铁死亡是一种受调控的细胞死亡形式,依赖于铁和活性氧。与凋亡、坏死和自噬不同,铁死亡的特征是细胞内脂质过氧化物的积累。研究发现,铁死亡与肿瘤的发生发展密切相关,诱导肿瘤细胞发生铁死亡可增强药物对肿瘤的治疗效果。本文综述了铁死亡在其机制以及与肿瘤相关性方面的最新研究进展,旨在为进一步理解铁死亡与肿瘤之间的相互作用机制提供参考,并为肿瘤治疗提供新的思路和靶点。

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