Department of Pharmacy, Clinical Pharmacy Center, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2021 Oct 25;50(5):601-606. doi: 10.3724/zdxbyxb-2021-0198.
Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxide accumulation, which is different from cell apoptosis, pyroptosis, necrosis or autophagy. Ferroptosis plays an important role in the regulation of tumorigenesis and tumor development. Recent studies have shown that natural medicinal ingredients can induce ferroptosis in tumor cells through glutathione (GSH)/glutathione peroxidase 4 (GPx4) pathway, iron metabolism, lipid metabolism or other mechanisms. It has been reported that more than 30 natural medicinal ingredients can induce ferroptosis in tumor cells with multiple pathways and multiple targets. This article reviews the current research progress on the antitumor effects of natural medicinal ingredients through inducing cell ferroptosis.
铁死亡是一种依赖于铁的程序性细胞死亡，其特征是活性氧诱导的脂质过氧化物积累，与细胞凋亡、细胞焦亡、坏死或自噬不同。铁死亡在肿瘤发生和发展的调控中发挥重要作用。最近的研究表明，天然药用成分可以通过谷胱甘肽（GSH）/谷胱甘肽过氧化物酶 4（GPx4）途径、铁代谢、脂质代谢或其他机制诱导肿瘤细胞发生铁死亡。据报道，超过 30 种天然药用成分可以通过多种途径和多个靶点诱导肿瘤细胞发生铁死亡。本文综述了通过诱导细胞铁死亡发挥抗肿瘤作用的天然药用成分的研究进展。
