Jason Leonard A, Ngonmedje Sarah
Center for Community Research, DePaul University, Chicago, IL 60614, USA.
Explor Med. 2024;5(2):185-192. doi: 10.37349/emed.2024.00215. Epub 2024 Apr 11.
It is unclear if individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with family histories of ME/CFS differ from those with ME/CFS without this family history. To explore this issue, quantitative data from patients with ME/CFS and controls were collected, and we examined those with and without family histories of ME/CFS.
The samples included 400 patients with ME/CFS, and a non-ME/CFS chronic illness control group of 241 patients with multiple sclerosis (MS) and 173 with post-polio syndrome (PPS).
Confirming findings from prior studies, those with ME/CFS were more likely to have family members with ME/CFS than controls. We found family histories of ME/CFS were significantly higher (18%) among the ME/CFS group than the non-ME/CFS controls (3.9%). In addition, patients with ME/CFS who had family histories of ME/CFS were more likely to have gastrointestinal symptoms than those with ME/CFS without those family histories.
Given the recent reports of gastrointestinal difficulties among those with ME/CFS, our findings might represent one predisposing factor for the emergence of ME/CFS.
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）患者中，有ME/CFS家族史的个体与无此家族史的个体是否存在差异尚不清楚。为探讨这一问题，我们收集了ME/CFS患者及对照的定量数据，并对有和无ME/CFS家族史的个体进行了研究。
样本包括400例ME/CFS患者，以及一个非ME/CFS慢性疾病对照组，其中241例为多发性硬化症（MS）患者，173例为小儿麻痹后遗症（PPS）患者。
与先前研究结果一致，ME/CFS患者比对照组更有可能有患ME/CFS的家庭成员。我们发现，ME/CFS组中有ME/CFS家族史的比例（18%）显著高于非ME/CFS对照组（3.9%）。此外，有ME/CFS家族史的ME/CFS患者比无此类家族史的ME/CFS患者更易出现胃肠道症状。
鉴于近期有报道称ME/CFS患者存在胃肠道问题，我们的研究结果可能代表了ME/CFS出现的一个 predisposing因素。 （注：“predisposing”此处可能是“诱发的、 predisposing因素暂无法准确翻译，推测为与引发疾病相关的某种因素” ，原文拼写或许有误，正确应为“predisposing” ）
