Bila Lubabalo, Putra Widya Pintaka Bayu, Malatji Dikeledi Petunia, Sanarana Yandisiwe Patience, Tyasi Thobela Louis
Department of Animal Production, Potchefstroom College of Agriculture, Potchefstroom, 2520, South Africa.
Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Florida, 1710, South Africa.
Heliyon. 2024 Oct 18;10(20):e39540. doi: 10.1016/j.heliyon.2024.e39540. eCollection 2024 Oct 30.
Sussex cattle () is one of beef cattle breeds in South Africa and it is possible to improve their genetic potential through genomic selection. The aim of this study was carried out to implement Genome-wide Association Study (GWAS) for determining candidate genes of body weights at birth, weaning and yearling stages in Sussex cattle. A total of 96 heads of Sussex cattle consisting of 45 females and 51 males were used for GWAS with Bovine 100K SNP BeadChip (Illumina, USA). The results showed that three SNP markers of BovineHD1000018504 (SNP1), BovineHD100008645 (SNP2) and BovineHD2500008434 (SNP3) were detected as the potential genetic markers for body weight of animals under this study. Among the three identified SNPs, SNP1 was not located in any gene region while SNP2 and SNP3 were located in the region of (intron 3) and (intron10) genes, respectively. Therefore, both the identified SNPs had the relationship with the body weight at different ages of the Sussex cattle based on the Manhattan plot graphic birth weight (BW) for SNP2 and weaning weight (WW) for SNP3. In conclusion, a significant association was observed between SNP3 and WW of South African Sussex cattle. Nonetheless, there are no association between SNP2 and BW of Sussex cattle.
苏塞克斯牛（）是南非的肉牛品种之一，通过基因组选择提高其遗传潜力是可行的。本研究旨在开展全基因组关联研究（GWAS），以确定苏塞克斯牛出生、断奶和周岁阶段体重的候选基因。共有96头苏塞克斯牛（45头雌性和51头雄性）用于使用牛100K SNP芯片（美国Illumina公司）进行的GWAS。结果表明，在本研究中，牛HD1000018504（SNP1）、牛HD100008645（SNP2）和牛HD2500008434（SNP3）这三个SNP标记被检测为动物体重的潜在遗传标记。在这三个已鉴定的SNP中，SNP1不在任何基因区域，而SNP2和SNP3分别位于（内含子3）和（内含子10）基因区域。因此，基于曼哈顿图，所鉴定的两个SNP都与苏塞克斯牛不同年龄的体重有关——SNP2与出生体重（BW）有关，SNP3与断奶体重（WW）有关。总之，观察到南非苏塞克斯牛的SNP3与WW之间存在显著关联。然而，苏塞克斯牛的SNP2与BW之间没有关联。
