Downar E, Butany J, Jares A, Stoicheff B P
J Am Coll Cardiol. 1986 Mar;7(3):546-50. doi: 10.1016/s0735-1097(86)80464-8.
A xenon-chlorine excimer laser was used to irradiate normal endocardium of fresh sheep and pig hearts as well as unfixed human endocardial scar. Forty pulses of 370 J and 35 ns each resulted in penetration of up to 12 mm in normal tissue and only 3.5 mm in scarred endocardium. Dosimetry indicated that the volume of vaporized scarred tissue was 1/10th that of normal endocardium (0.19 to 0.40 versus 1.35 to 3.22 mm3/J). Ultrastructurally, there was a sharp demarcation of only 10 mu between the region of injury and normal myocardium, with little evidence of heat injury. The high power and short duration of these lasers coupled with the lack of a boundary zone of injury suggest that excimers may be an ideal tool for arrhythmia ablation.
使用氙氯准分子激光照射新鲜绵羊和猪心脏的正常心内膜以及未固定的人类心内膜瘢痕。每次370焦耳、35纳秒的40个脉冲在正常组织中可穿透达12毫米，而在瘢痕化心内膜中仅为3.5毫米。剂量测定表明，汽化的瘢痕组织体积是正常心内膜的1/10（0.19至0.40立方毫米/焦耳对1.35至3.22立方毫米/焦耳）。超微结构显示，损伤区域与正常心肌之间仅有10微米的清晰界限，几乎没有热损伤的迹象。这些激光的高功率和短持续时间以及缺乏损伤边界区表明，准分子激光可能是心律失常消融的理想工具。
