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眼部赛多孢子菌病:病例系列

Ocular scedosporiosis: A case series.

作者信息

Turner Marcus L, Nguyen Minh, Schallhorn Julie, Seitzman Gerami D

机构信息

Department of Ophthalmology, University of Washington, Seattle, WA, USA.

Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.

出版信息

Am J Ophthalmol Case Rep. 2024 Oct 16;36:102190. doi: 10.1016/j.ajoc.2024.102190. eCollection 2024 Dec.

Abstract

PURPOSE

To report five cases of ocular scedosporiosis with associated predisposing factors, treatment courses, and clinical outcomes.

OBSERVATION

This case series consists of 5 patients diagnosed with ocular scedosporiosis. Two patients were female and 3 were male. The average age was 68.4 years (range 53-85). Four of the 5 had a clear history of ocular surgery or ocular trauma with organic foreign material. Two developed sclero-keratitis. Two had cornea-only involvement. There was 1 scleritis-only case. Patients with scleritis required topical and systemic treatment. Patients with only keratitis were treated topically. The two patients with sclero-keratitis ultimately progressed to eye removal despite maximal therapy.

CONCLUSION AND IMPORTANCE

Ocular scedosporiosis is exceedingly rare, especially in the Unites States. We highlight similarities and differences of five ocular scedosporiosis cases. Most cases involved either ocular surgery or contamination with ground or plant matter. This case series highlights the challenge of the diagnosis and the aggressivity of this disease.

摘要

目的

报告5例眼部赛多孢子菌病病例,包括相关的易感因素、治疗过程及临床结果。

观察

该病例系列包括5例被诊断为眼部赛多孢子菌病的患者。其中2例为女性,3例为男性。平均年龄为68.4岁(范围53 - 85岁)。5例中有4例有明确的眼部手术史或眼部外伤伴有机异物史。2例发展为硬化性角膜炎。2例仅角膜受累。有1例仅为巩膜炎。巩膜炎患者需要局部和全身治疗。仅角膜炎患者接受局部治疗。尽管进行了最大程度的治疗,2例硬化性角膜炎患者最终仍进展至眼球摘除。

结论与重要性

眼部赛多孢子菌病极为罕见,尤其是在美国。我们强调了5例眼部赛多孢子菌病病例的异同点。大多数病例涉及眼部手术或被土壤或植物物质污染。该病例系列突出了该病诊断的挑战性及侵袭性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effb/11535890/4245308e5944/gr1.jpg

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