Zhu Yajun, Liu Wenhui, Luo Zhiying, Xiao Feiyan, Sun Bao
Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
Institute of Clinical Pharmacy, Central South University, Changsha, China.
Front Pharmacol. 2024 Oct 22;15:1412672. doi: 10.3389/fphar.2024.1412672. eCollection 2024.
Lactylation, a novel discovered posttranslational modification, is a vital component of lactate function and is prevalent in a wide range of cells, interacting with both histone and non-histone proteins. Recent studies have confirmed that lactylation as a new contributor to epigenetic landscape is involved in multiple pathological processes. Accumulating evidence reveals that lactylation exists in different pathophysiological states and leads to inflammation and cancer; however, few mechanisms of lactylation have been elaborated. This review summarizes the biological processes and pathophysiological roles of lactylation in cancer, as well as discusses the relevant mechanisms and potential therapeutic targets, aiming to provide new insights for targeted cancer therapy.
乳酰化是一种新发现的翻译后修饰，是乳酸功能的重要组成部分，广泛存在于多种细胞中，可与组蛋白和非组蛋白相互作用。最近的研究证实，乳酰化作为表观遗传格局的新贡献者，参与了多种病理过程。越来越多的证据表明，乳酰化存在于不同的病理生理状态中，并导致炎症和癌症；然而，乳酰化的机制鲜有阐述。本综述总结了乳酰化在癌症中的生物学过程和病理生理作用，并讨论了相关机制和潜在的治疗靶点，旨在为癌症靶向治疗提供新的见解。
