Kavitha Mahendran, Krishnaveni Raju, Jaikailash Shanmugam, Ranjani Muthukrishnan Sudharshana, Hemamalini Rangarajan, Rohit Kakade Madhura
Department of Conservative Dentistry & Endodontics, Tamil Nadu Government Dental College & Hospital, Chennai. The Tamil Nadu Dr. M. G. R. Medical University, Chennai, Tamil Nadu, India.
Dental Surgeon, Government Hospital, Kotagiri, Nilgiris, Tamil Nadu, India.
Med Pharm Rep. 2024 Oct;97(4):549-556. doi: 10.15386/mpr-2637. Epub 2024 Oct 30.
Platelet concentrates are currently being researched for their potential to enhance bone formation.
The aim of this study is to quantitatively evaluate and compare bone regeneration in periapical lesions using a combination of platelet-rich plasma (PRP) + β-tricalcium phosphate (β-TCP) and platelet-rich fibrin (PRF) + β-TCP.
Ten subjects with periapical lesions measuring 10-20 mm in relation to maxillary incisors indicated for periapical surgery were selected. Pre-operative bone density values at the periapical region were measured using CBCT. Root canal treatment was completed appropriately in all cases. Under adequate local anesthesia, periapical surgery was performed. The 10 subjects were distributed into two groups of 5 subjects in each group. Group I: Periapical bone defect filled with PRP + β-TCP and Group II: Periapical bone defect filled with PRF + β-TCP. The mucoperiosteal flaps were repositioned and sutured. Bone density evaluation of the periapical region was done 6 months and 1 year after surgery using cone beam computed tomography (CBCT). The Hounsfield unit (HU) values obtained were subjected to statistical analysis by Independent samples t-test for inter-group comparison. The intra-group comparison was done by repeated measure ANOVA and Bonferroni post hoc tests.
In Group I and Group II, a statistically significant difference was observed at the end of 6 months and 1 year, when compared to the pre-operative values (P=0.000). There was no statistically significant difference in bone density values between the PRP + β-TCP and PRF + β-TCPgroups at both 6 months and 1-year post-operative observation periods.
PRP + β-TCP and PRF + β-TCP were equally effective in promoting bone regeneration and can be considered valuable bioactive surgical additives for enhancement of healing in periapical bone defects.
目前正在研究血小板浓缩物促进骨形成的潜力。
本研究旨在定量评估和比较富血小板血浆（PRP）+β-磷酸三钙（β-TCP）与富血小板纤维蛋白（PRF）+β-TCP联合应用于根尖周病变骨再生的情况。
选择10例上颌切牙根尖周病变大小为10 - 20 mm、拟行根尖周手术的患者。术前使用锥形束计算机断层扫描（CBCT）测量根尖周区域的骨密度值。所有病例均适当完成根管治疗。在充分局部麻醉下进行根尖周手术。10例患者分为两组，每组5例。第一组：根尖周骨缺损用PRP +β-TCP填充；第二组：根尖周骨缺损用PRF +β-TCP填充。将粘骨膜瓣复位并缝合。术后6个月和1年使用锥形束计算机断层扫描（CBCT）对根尖周区域进行骨密度评估。通过独立样本t检验对获得的亨氏单位（HU）值进行组间比较的统计分析。组内比较采用重复测量方差分析和Bonferroni事后检验。
与术前值相比，第一组和第二组在6个月和1年结束时均观察到统计学上的显著差异（P = 0.000）。在术后6个月和1年的观察期内，PRP +β-TCP组和PRF +β-TCP组之间的骨密度值无统计学显著差异。
PRP +β-TCP和PRF +β-TCP在促进骨再生方面同样有效，可被视为用于增强根尖周骨缺损愈合的有价值的生物活性手术添加剂。
