Wang Yingli, Jiang Yalin, Xie Meiling, Qi Bin, Pu Kunpeng, Du Wenjie, Zhang Qingqing, Ma Mengmeng, Chen Ziyong, Guo Yongxia, Qian Hui, Wang Kaiqin, Tian Tulei, Fu Lin, Zhang Xiaofei
Bengbu Medical University Graduate School, Bengbu, Anhui, People's Republic of China.
Department of Respiratory and Critical Care Medicine, The Affiliated Bozhou Hospital of Anhui Medical University, Bozhou, Anhui, People's Republic of China.
J Inflamm Res. 2024 Nov 1;17:7951-7962. doi: 10.2147/JIR.S485932. eCollection 2024.
Leucine-rich α-2 glycoprotein 1 (LRG1) is associated with various inflammatory lung diseases. Nevertheless, the connection between LRG1 and adult community-acquired pneumonia (CAP) individuals was still not well understood. Through a prospective cohort study, the correlations of serum LRG1 with severity and prognosis were evaluated in CAP patients.
The study encompassed 327 patients who received the diagnosis of CAP. We collected fasting venous blood and clinical features. Serum LRG1 was detected by ELISA. CAP severity was assessed using various scoring systems. The prognostic outcomes were observed through follow-up visits.
The level of serum LRG1 at admission was gradually increased with CAP severity scores. Serum LRG1 level shown positive associations with inflammatory indices, including C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6). Linear and logistic regression analyses suggested that serum LRG1 at admission was positively associated with severity scores and the risk of death in CAP patients. Serum LRG1 in combination with CAP severity scores significantly increased the predictive powers for severity and death compared with single serum LRG1 or severity scores.
The study revealed positive connections of serum LRG1 levels with severity and poor prognosis in CAP patients, suggesting LRG1 partakes into the physiological processes of CAP. Serum LRG1 may be regarded as a potential biomarker in predicting the severity and death among CAP patients.
富含亮氨酸的α-2糖蛋白1（LRG1）与多种炎症性肺部疾病相关。然而，LRG1与成人社区获得性肺炎（CAP）患者之间的联系仍未得到充分了解。通过一项前瞻性队列研究，评估了CAP患者血清LRG1与病情严重程度和预后的相关性。
该研究纳入了327例被诊断为CAP的患者。我们收集了空腹静脉血和临床特征。采用酶联免疫吸附测定法检测血清LRG1。使用各种评分系统评估CAP的严重程度。通过随访观察预后结果。
入院时血清LRG1水平随CAP严重程度评分逐渐升高。血清LRG1水平与炎症指标呈正相关，包括C反应蛋白（CRP）、降钙素原（PCT）和白细胞介素-6（IL-6）。线性和逻辑回归分析表明，入院时血清LRG1与CAP患者的严重程度评分和死亡风险呈正相关。与单一血清LRG1或严重程度评分相比，血清LRG1与CAP严重程度评分相结合显著提高了对严重程度和死亡的预测能力。
该研究揭示了CAP患者血清LRG1水平与病情严重程度和不良预后之间的正相关关系，表明LRG1参与了CAP的生理过程。血清LRG1可被视为预测CAP患者严重程度和死亡的潜在生物标志物。
