Second Clinical Medical College, Anhui Medical University, Hefei, China.
Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Front Immunol. 2021 May 7;12:636896. doi: 10.3389/fimmu.2021.636896. eCollection 2021.
Recent evidences suggested that IL-37 may participate in the pathophysiology of community-acquired pneumonia (CAP). Nevertheless, its exact biological role was unknown. The objective of this study was to determine the associations of serum IL-37 with the severity and prognosis in CAP patients based on a retrospective cohort study.
The whole of 120 healthy subjects and 240 CAP patients were summoned. Peripheral blood was collected and IL-37 was detected using ELISA.
Serum IL-37 was obviously decreased in CAP patients on admission. In addition, serum IL-37 was gradually decreased in parallel with CAP severity scores. Correlative analysis revealed that serum IL-37 was negatively associated with CAP severity scores and inflammatory cytokines. Further logistical regression found that reduction of serum IL-37 augmented the severity of CAP patients. Moreover, the follow-up research was performed in CAP patients. Serum lower IL-37 on admission prolonged the hospital stay in CAP patients. Serum IL-37 combination with PSI and CURB-65 had a stronger predictive capacity for death than IL-37 and CAP severity score alone in CAP patients.
There are remarkably negative correlations between serum IL-37 with the severity and prognosis in CAP patients. Serum IL-37 on admission prolongs the hospital stay, demonstrating that IL-37 may involve in the process of CAP. Serum IL-37 may be regarded as a biomarker for diagnosis and prognosis for CAP patients.
最近的证据表明，IL-37 可能参与社区获得性肺炎 (CAP) 的病理生理学。然而，其确切的生物学作用尚不清楚。本研究旨在通过回顾性队列研究确定血清 IL-37 与 CAP 患者严重程度和预后的相关性。
共召集了 120 名健康受试者和 240 名 CAP 患者。采集外周血，采用 ELISA 法检测 IL-37。
入院时 CAP 患者血清 IL-37 明显降低。此外，血清 IL-37 随着 CAP 严重程度评分逐渐降低。相关分析表明，血清 IL-37 与 CAP 严重程度评分和炎症细胞因子呈负相关。进一步的逻辑回归发现，血清 IL-37 的降低增加了 CAP 患者的严重程度。此外，对 CAP 患者进行了随访研究。入院时血清 IL-37 降低会延长 CAP 患者的住院时间。与 IL-37 和 CAP 严重程度评分单独相比，血清 IL-37 与 PSI 和 CURB-65 的联合对 CAP 患者的死亡具有更强的预测能力。
血清 IL-37 与 CAP 患者的严重程度和预后呈显著负相关。入院时血清 IL-37 延长了住院时间，表明 IL-37 可能参与了 CAP 的发生过程。血清 IL-37 可作为 CAP 患者诊断和预后的生物标志物。
