血清 IL-37 与社区获得性肺炎患者严重程度和预后的关系：一项回顾性队列研究。
The Associations of Serum IL-37 With the Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Retrospective Cohort Study.
机构信息
Second Clinical Medical College, Anhui Medical University, Hefei, China.
Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, China.
出版信息
Front Immunol. 2021 May 7;12:636896. doi: 10.3389/fimmu.2021.636896. eCollection 2021.
BACKGROUND
Recent evidences suggested that IL-37 may participate in the pathophysiology of community-acquired pneumonia (CAP). Nevertheless, its exact biological role was unknown. The objective of this study was to determine the associations of serum IL-37 with the severity and prognosis in CAP patients based on a retrospective cohort study.
METHODS
The whole of 120 healthy subjects and 240 CAP patients were summoned. Peripheral blood was collected and IL-37 was detected using ELISA.
RESULTS
Serum IL-37 was obviously decreased in CAP patients on admission. In addition, serum IL-37 was gradually decreased in parallel with CAP severity scores. Correlative analysis revealed that serum IL-37 was negatively associated with CAP severity scores and inflammatory cytokines. Further logistical regression found that reduction of serum IL-37 augmented the severity of CAP patients. Moreover, the follow-up research was performed in CAP patients. Serum lower IL-37 on admission prolonged the hospital stay in CAP patients. Serum IL-37 combination with PSI and CURB-65 had a stronger predictive capacity for death than IL-37 and CAP severity score alone in CAP patients.
CONCLUSION
There are remarkably negative correlations between serum IL-37 with the severity and prognosis in CAP patients. Serum IL-37 on admission prolongs the hospital stay, demonstrating that IL-37 may involve in the process of CAP. Serum IL-37 may be regarded as a biomarker for diagnosis and prognosis for CAP patients.
背景
最近的证据表明，IL-37 可能参与社区获得性肺炎 (CAP) 的病理生理学。然而，其确切的生物学作用尚不清楚。本研究旨在通过回顾性队列研究确定血清 IL-37 与 CAP 患者严重程度和预后的相关性。
方法
共召集了 120 名健康受试者和 240 名 CAP 患者。采集外周血，采用 ELISA 法检测 IL-37。
结果
入院时 CAP 患者血清 IL-37 明显降低。此外，血清 IL-37 随着 CAP 严重程度评分逐渐降低。相关分析表明，血清 IL-37 与 CAP 严重程度评分和炎症细胞因子呈负相关。进一步的逻辑回归发现，血清 IL-37 的降低增加了 CAP 患者的严重程度。此外，对 CAP 患者进行了随访研究。入院时血清 IL-37 降低会延长 CAP 患者的住院时间。与 IL-37 和 CAP 严重程度评分单独相比，血清 IL-37 与 PSI 和 CURB-65 的联合对 CAP 患者的死亡具有更强的预测能力。
结论
血清 IL-37 与 CAP 患者的严重程度和预后呈显著负相关。入院时血清 IL-37 延长了住院时间，表明 IL-37 可能参与了 CAP 的发生过程。血清 IL-37 可作为 CAP 患者诊断和预后的生物标志物。
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