新辅助PD-1/PD-L1抑制剂联合化疗用于可切除的胃癌和胃食管交界癌 - Suppr

Neoadjuvant PD-1/PD-L1 inhibitors plus chemotherapy in resectable gastric and gastroesophageal junction cancer.

作者信息

Taherifard Erfan, Saeed Anwaar

机构信息

Department of Medicine, Division of Hematology & Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

出版信息

Transl Gastroenterol Hepatol. 2024 Aug 14;9:59. doi: 10.21037/tgh-24-44. eCollection 2024.

DOI:10.21037/tgh-24-44

PMID:39503035

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11535811/

Abstract

摘要

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Neoadjuvant PD-1/PD-L1 inhibitors plus chemotherapy in resectable gastric and gastroesophageal junction cancer.新辅助PD-1/PD-L1抑制剂联合化疗用于可切除的胃癌和胃食管交界癌

Transl Gastroenterol Hepatol. 2024 Aug 14;9:59. doi: 10.21037/tgh-24-44. eCollection 2024.

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Expression of programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand (PD-L1) in adenocarcinomas of the gastroesophageal junction change significantly after neoadjuvant treatment.在新辅助治疗后，胃食管交界处腺癌中程序性细胞死亡蛋白 1（PD-1）和程序性细胞死亡配体 1（PD-L1）的表达发生显著变化。

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Clinical outcomes and biomarker exploration of first-line PD-1 inhibitors plus chemotherapy in patients with low PD-L1-expressing of gastric or gastroesophageal junction adenocarcinoma.一线 PD-1 抑制剂联合化疗治疗低 PD-L1 表达的胃或胃食管结合部腺癌患者的临床结局和生物标志物探索。

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Neoadjuvant immunotherapy improves outcomes for resectable gastroesophageal junction cancer: A systematic review and meta-analysis.新辅助免疫疗法改善可切除胃食管交界癌的预后：系统评价和荟萃分析。

Cancer Med. 2024 May;13(9):e7176. doi: 10.1002/cam4.7176.

Neoadjuvant chemoimmunotherapy in locally advanced gastric or gastroesophageal junction adenocarcinoma.局部晚期胃癌或胃食管交界腺癌的新辅助化疗免疫疗法

Front Oncol. 2024 Apr 15;14:1342162. doi: 10.3389/fonc.2024.1342162. eCollection 2024.

Evaluation of neoadjuvant immunotherapy in resectable gastric/gastroesophageal junction tumors: a meta-analysis and systematic review.可切除胃/胃食管交界肿瘤新辅助免疫治疗的评价：荟萃分析和系统评价。

Front Immunol. 2024 Jan 30;15:1339757. doi: 10.3389/fimmu.2024.1339757. eCollection 2024.

Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer.早期免疫重塑指导晚期胃癌一线化疗免疫治疗的临床应答。

Cancer Discov. 2024 May 1;14(5):766-785. doi: 10.1158/2159-8290.CD-23-0857.

Nat Med. 2024 Feb;30(2):519-530. doi: 10.1038/s41591-023-02758-x. Epub 2024 Jan 8.

Neoadjuvant and adjuvant pembrolizumab plus chemotherapy in locally advanced gastric or gastro-oesophageal cancer (KEYNOTE-585): an interim analysis of the multicentre, double-blind, randomised phase 3 study.新辅助和辅助帕博利珠单抗联合化疗治疗局部晚期胃或胃食管交界癌（KEYNOTE-585）：多中心、双盲、随机 3 期研究的中期分析。

Lancet Oncol. 2024 Feb;25(2):212-224. doi: 10.1016/S1470-2045(23)00541-7. Epub 2023 Dec 19.

Perioperative Atezolizumab Plus Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel for Resectable Esophagogastric Cancer: Interim Results From the Randomized, Multicenter, Phase II/III DANTE/IKF-s633 Trial.可切除食管胃结合部腺癌患者围手术期使用阿替利珠单抗联合氟尿嘧啶、亚叶酸钙、奥沙利铂和多西他赛治疗的随机、多中心、Ⅱ/Ⅲ期 DANTE/IKF-s633 试验的中期结果。

J Clin Oncol. 2024 Feb 1;42(4):410-420. doi: 10.1200/JCO.23.00975. Epub 2023 Nov 14.

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J Clin Oncol. 2023 Mar 1;41(7):1470-1491. doi: 10.1200/JCO.22.02331. Epub 2023 Jan 5.

Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer.局部进展期胃癌的免疫检查点阻断、抗血管生成和化疗的新辅助治疗。

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Neoadjuvant PD-1/PD-L1 inhibitors plus chemotherapy in resectable gastric and gastroesophageal junction cancer.

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