Adjei-Mensah Evelyn, Alhassan Yakubu, Owusu Richmond, Kretchy Irene A
Public Health Unit, Korle Bu Teaching Hospital, P. O. Box 77, korlebu, Accra, Ghana.
Department of Community Health, University of Ghana Medical School, P. O. Box LG 25 Legon, Accra, Ghana.
Trans R Soc Trop Med Hyg. 2025 Feb 4;119(2):135-144. doi: 10.1093/trstmh/trae091.
Without a cure, antiretroviral therapy (ART) continues to be the primary mode of managing HIV, transforming it from a formerly lethal disease to a less severe one. Adherence to ART can be impacted by several factors, including poor quality of care.
A quantitative cross-sectional study design was used to assess the factors that influence adherence to ART among adults receiving care at two health facilities in Accra. A structured interviewer-administered questionnaire was used to collect data on factors associated with medication adherence using a modified four-item Medication Adherence Rating from 255 people living with HIV (PLHIV). Descriptive statistics were used to summarise the data, while multiple binary logistic regression was used to assess the factors influencing adherence to ART.
Adherence to HIV medication was 44.7% among PLHIV. Adherence was positively correlated with high client health service satisfaction (adjusted OR [AOR]: 26.59, 95% CI 7.46 to 94.82, p<0.001), increased privacy at the HIV clinics (AOR: 3.40, 95% CI 1.40 to 8.21, p<0.007) and among PLHIV who had been diagnosed with HIV for ≥5 y (AOR: 7.59, 95% CI 2.76 to 20.85, p<0.001).
Adherence to ART was significantly low among study participants. The study highlights the importance of maintaining privacy and confidentiality at the facility while ensuring client satisfaction with HIV care to promote adherence to ART.
由于尚无治愈方法，抗逆转录病毒疗法（ART）仍然是管理艾滋病毒的主要方式，使这种从前的致命疾病转变为一种不太严重的疾病。坚持接受抗逆转录病毒疗法可能会受到多种因素的影响，包括护理质量差。
采用定量横断面研究设计，以评估在阿克拉的两家医疗机构接受护理的成年人中影响抗逆转录病毒疗法依从性的因素。使用结构化的访谈问卷，通过修改后的四项药物依从性评分，从255名艾滋病毒感染者（PLHIV）中收集与药物依从性相关因素的数据。描述性统计用于汇总数据，多元二元逻辑回归用于评估影响抗逆转录病毒疗法依从性的因素。
艾滋病毒感染者中抗逆转录病毒药物的依从率为44.7%。依从性与较高的患者健康服务满意度呈正相关（调整后的比值比[AOR]：26.59，95%置信区间7.46至94.82，p<0.001），在艾滋病毒诊所隐私性增加（AOR：3.40，95%置信区间1.40至8.21，p<0.007）以及在被诊断出感染艾滋病毒≥5年的艾滋病毒感染者中（AOR：7.59，95%置信区间2.76至20.85，p<0.001）。
研究参与者中抗逆转录病毒疗法的依从性显著较低。该研究强调了在医疗机构保持隐私和保密性的重要性，同时确保患者对艾滋病毒护理的满意度，以促进对抗逆转录病毒疗法的依从性。
