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Soluble epoxide hydrolase: a next-generation drug target for Alzheimer's disease and related dementias.

作者信息

Gregory Andrew, Tang Chengyun, Fan Fan

机构信息

Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, USA.

出版信息

Neural Regen Res. 2025 Sep 1;20(9):2585-2586. doi: 10.4103/NRR.NRR-D-24-00503. Epub 2024 Sep 6.

DOI:10.4103/NRR.NRR-D-24-00503
PMID:39503424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11801286/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c52f/11801286/401c1c1d2baa/NRR-20-2585-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c52f/11801286/401c1c1d2baa/NRR-20-2585-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c52f/11801286/401c1c1d2baa/NRR-20-2585-g001.jpg

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本文引用的文献

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Amyloid beta accumulation in TgF344-AD rats is associated with reduced cerebral capillary endothelial Kir2.1 expression and neurovascular uncoupling.TgF344-AD 大鼠脑内淀粉样β沉积与脑毛细血管内皮 Kir2.1 表达减少和神经血管解偶联有关。
Geroscience. 2023 Oct;45(5):2909-2926. doi: 10.1007/s11357-023-00841-2. Epub 2023 Jun 16.
2
Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer's disease.阿尔茨海默病 TgF344-AD 大鼠模型中脑血流动力学的纵向特征。
Geroscience. 2023 Jun;45(3):1471-1490. doi: 10.1007/s11357-023-00773-x. Epub 2023 Mar 18.
3
Impact of impaired cerebral blood flow autoregulation on cognitive impairment.
脑血流自动调节受损对认知障碍的影响。
Front Aging. 2022 Dec 2;3:1077302. doi: 10.3389/fragi.2022.1077302. eCollection 2022.
4
From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia?从 1901 年到 2022 年，我们离真正了解与年龄相关的痴呆症的发病机制还有多远？
Geroscience. 2022 Jun;44(3):1879-1883. doi: 10.1007/s11357-022-00591-7. Epub 2022 May 19.
5
Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels.创伤性脑损伤通过破坏内向整流钾通道损害全身血管功能。
Function (Oxf). 2021;2(3). doi: 10.1093/function/zqab018. Epub 2021 Apr 6.
6
Reversal of cerebral hypoperfusion: a novel therapeutic target for the treatment of AD/ADRD?脑灌注不足的逆转：治疗 AD/ADRD 的新治疗靶点？
Geroscience. 2021 Apr;43(2):1065-1067. doi: 10.1007/s11357-021-00357-7. Epub 2021 Mar 27.
7
Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative.运动至可溶环氧化物水解酶抑制剂 EC5026 的临床应用作为治疗神经性疼痛的镇痛药，也可作为非成瘾性阿片类药物替代物。
J Med Chem. 2021 Feb 25;64(4):1856-1872. doi: 10.1021/acs.jmedchem.0c01886. Epub 2021 Feb 7.
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An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease.一种环氧水解酶抑制剂可减轻阿尔茨海默病小鼠模型中的神经炎症。
Sci Transl Med. 2020 Dec 9;12(573). doi: 10.1126/scitranslmed.abb1206.
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BMC Neurosci. 2020 Oct 31;21(1):43. doi: 10.1186/s12868-020-00596-y.
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Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats.衰老使糖尿病大鼠的大脑血流自动调节和认知功能损伤恶化。
Geroscience. 2020 Oct;42(5):1387-1410. doi: 10.1007/s11357-020-00233-w. Epub 2020 Jul 21.