通过修饰[具体对象]中的染色体AmpCβ-内酰胺酶而出现对头孢他啶/阿维巴坦的耐药性 。 （注：原文中“in.”后面缺少具体信息）
emergence of resistance to ceftazidime/avibactam through modification of chromosomal AmpC β-lactamase in .
作者信息
Rodríguez-Pallares Salud, Blanco-Martín Tania, Lence Emilio, Aja-Macaya Pablo, Sánchez-Peña Lucía, González-Pinto Lucía, Rodríguez-Mayo María, Fernández-González Ana, Galán-Sánchez Fátima, Beceiro Alejandro, González-Bello Concepción, Bou Germán, Arca-Suárez Jorge
机构信息
Servicio de Microbiología and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, A Coruña, Spain.
Departamento de Química Orgánica, Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
出版信息
Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0130724. doi: 10.1128/aac.01307-24. Epub 2024 Nov 6.
We describe the emergence of resistance to ceftazidime/avibactam via modification of AmpC in a clinical isolate during therapy with this combination. Paired ceftazidime/avibactam-susceptible/resistant isolates were obtained before and during ceftazidime/avibactam treatment. Whole genome sequencing revealed a differential mutation in AmpC (R148W) in the ceftazidime/avibactam-resistant isolate. Molecular cloning and structural studies confirmed the impact of this substitution, which affects the architecture of the H10 helix, on the evolved resistant phenotype.
我们描述了在使用头孢他啶/阿维巴坦联合治疗期间，临床分离株中通过AmpC修饰产生对头孢他啶/阿维巴坦的耐药性。在头孢他啶/阿维巴坦治疗前和治疗期间获得了配对的对头孢他啶/阿维巴坦敏感/耐药的分离株。全基因组测序显示，在对头孢他啶/阿维巴坦耐药的分离株中，AmpC存在差异突变（R148W）。分子克隆和结构研究证实了这种影响H10螺旋结构的替代对进化出的耐药表型的作用。
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