Cao Hongliang, Shi Chengdong, Aihemaiti Zulipikaer, Dai Xianyu, Yu Fangqiu, Wang Song
Department of Urology, The First Hospital of Jilin University, Changchun, 130021, China.
Department of Urology, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi City, 830002, China.
Int Urol Nephrol. 2025 Mar;57(3):965-971. doi: 10.1007/s11255-024-04275-3. Epub 2024 Nov 6.
Complex nexuses between obesity and chronic kidney disease (CKD) have been reported. Nevertheless, the link between the body roundness index (BRI), an indicator utilized to measure body fat distribution, and CKD risk has been unexplored.
We utilized publicly available data from ten survey cycles (1999-2018) of the National Health and Nutrition Examination Survey (NHANES) in the United States. We examined the association between BRI and CKD risk using multivariable logistic regression, subgroup analysis, interaction tests, and smooth curve fitting.
The study ultimately involved 41,953 participants, 3,123 (7.44%) of whom had CKD. Multivariable logistic regression, adjusted for covariates, identified high BRI levels in quartile 4 as a risk factor for CKD (OR = 1.30, 95% CI 1.12-1.50, P = 0.0005). This association remained consistent across subgroups (P for interaction > 0.05). Smoothed curve fitting exhibited a roughly linear positive correlation between BRI and CKD.
According to our study, BRI was related to CKD in a roughly linear way, suggesting a novel indicator for improving prevention and treatment for the CKD population. Nevertheless, additional research is needed to identify the association.
肥胖与慢性肾脏病（CKD）之间存在复杂的联系已被报道。然而，用于测量体脂分布的指标——身体圆润度指数（BRI）与CKD风险之间的联系尚未得到探索。
我们使用了美国国家健康与营养检查调查（NHANES）十个调查周期（1999 - 2018年）的公开数据。我们使用多变量逻辑回归、亚组分析、交互作用检验和平滑曲线拟合来研究BRI与CKD风险之间的关联。
该研究最终纳入41,953名参与者，其中3,123人（7.44%）患有CKD。经协变量调整的多变量逻辑回归分析确定，四分位数4中的高BRI水平是CKD的一个风险因素（OR = 1.30，95% CI 1.12 - 1.50，P = 0.0005）。这种关联在各亚组中保持一致（交互作用P > 0.05）。平滑曲线拟合显示BRI与CKD之间大致呈线性正相关。
根据我们的研究，BRI与CKD大致呈线性相关，这表明它是改善CKD人群预防和治疗的一个新指标。然而，需要进一步的研究来确定这种关联。
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