Zhang Yujun, Song Jingjing, Li Benjie, Wu Yunhao, Jia Shengjun, Shu Hongxin, Liu Fang, Yang Xiaorong
Department of Urology Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China.
Huankui Academy, Nanchang University, Nanchang, Jiangxi, 330006, China.
Lipids Health Dis. 2024 Jun 12;23(1):184. doi: 10.1186/s12944-024-02174-1.
An increasing amount of research has indicated obesity greatly affects individuals with overactive bladder (OAB). However, traditional anthropometric methods present challenges in accurately assessing the likelihood of OAB. Hence, this study's objective was to identify the correlation between the body roundness index (BRI) and OAB.
The research included 12,401 individuals who participated in the National Health and Nutrition Examination Survey spanning 2005-2018. The correlation between BRI and OAB was explored by using weighted multiple logistic regression and weighted restricted cubic spline (RCS). Subgroup analyses showed the associations based on different population types. The study also analyzed the predictive capability of various anthropometric indices, including BRI, body mass index, waist circumference, and weight, in assessing the likelihood of OAB through Receiver-operating characteristic (ROC) curves.
An independent positive correlation between OAB and BRI was identified after adjusting for potential confounders in weighted multivariate logistic models[odds ratio (OR) = 1.15, 95% confidence interval (CI), 1.12-1.17]. Weighted RCS analysis found a positive dose-response correlation between OAB and BRI. The effect size of BRI on OAB remained stable across all prespecified subgroups (all P for interactions > 0.05). In ROC analysis, BRI showed better discriminatory ability for OAB compared with other anthropometric measures for both genders (all P < 0.01). The best BRI cutoff for predicting OAB was lower for men (5.151) than for women (5.383), suggesting that men were more susceptible to changes in BRI than women.
This study demonstrated that a raised BRI is correlated with a higher likelihood of OAB. Due to the effectiveness and non-invasiveness of BRI in predicting OAB, it is expected to become the preferred method for early detection and management strategies.
越来越多的研究表明，肥胖对膀胱过度活动症（OAB）患者有很大影响。然而，传统人体测量方法在准确评估OAB发生可能性方面存在挑战。因此，本研究的目的是确定身体圆润度指数（BRI）与OAB之间的相关性。
该研究纳入了2005年至2018年参加美国国家健康与营养检查调查的12401名个体。采用加权多元逻辑回归和加权受限立方样条（RCS）法探究BRI与OAB之间的相关性。亚组分析显示了基于不同人群类型的关联。该研究还通过受试者工作特征（ROC）曲线分析了包括BRI、体重指数、腰围和体重在内的各种人体测量指标在评估OAB发生可能性方面的预测能力。
在加权多变量逻辑模型中对潜在混杂因素进行校正后，发现OAB与BRI之间存在独立正相关[比值比（OR）=1.15，95%置信区间（CI）为1.12 - 1.17]。加权RCS分析发现OAB与BRI之间存在正剂量反应关系。在所有预先设定的亚组中，BRI对OAB的效应大小保持稳定（所有交互作用P>0.05）。在ROC分析中，与其他人体测量指标相比，BRI对男女OAB均显示出更好的鉴别能力（所有P<0.01）。预测OAB的最佳BRI临界值男性（5.151）低于女性（5.383），表明男性比女性更容易受到BRI变化的影响。
本研究表明，升高的BRI与OAB发生可能性较高相关。由于BRI在预测OAB方面具有有效性和非侵入性，有望成为早期检测和管理策略的首选方法。
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