Department of Critical Care Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Front Endocrinol (Lausanne). 2024 Aug 5;15:1390725. doi: 10.3389/fendo.2024.1390725. eCollection 2024.
To compare the dietary inflammatory index (DII), triglyceride glucose index (TyG), waist triglyceride index (WTI), and body mass index (BMI) in predicting the survival of chronic kidney disease (CKD).
Inclusion of 23,099 participants from the NHANES database who met specific criteria. Baseline was established using quartiles of DII index. The relationship between DII index, WTI index, TyG index, and BMI index with mortality rate in CKD patients was evaluated using Kaplan-Meier curves. Univariate and multivariate COX regression risk models were used to study the relationship between DII index, WTI index, and TyG index with mortality risk in CKD patients. Stratification of eGFR by age and gender was conducted to investigate the association between DII index, WTI index, and TyG index with mortality risk in CKD patients. Restricted cubic spline analysis was used to study the correlation between DII index, WTI index, and TyG index with mortality risk in CKD patients.
The incidence of CKD increased with the increase of DII index, WTI index and TyG index. After multivariable adjustment, the fourth quartile of DII index, TyG index and WTI index showed the highest risk for CKD [DII: hazard ratio (HR) 1.36, 95% confidential interval (CI) (1.23-1.51); TyG: HR 1.21; 95% CI (1.07-1.37); WTI: HR 1.29; 95% CI (1.13-1.46)]. There was no difference in the risk of developing CKD between the obese group (BMI ≥24 kg/m2) and the normal weight group (P>0.05).
This study has identified a significant association between elevated DII index, WTI index, and TyG index with the risk of CKD. Furthermore, the DII index demonstrated superior prognostic capability in predicting CKD compared to other indicators.
比较膳食炎症指数（DII）、甘油三酯-葡萄糖指数（TyG）、腰围甘油三酯指数（WTI）和体重指数（BMI）在预测慢性肾脏病（CKD）患者生存中的作用。
纳入 NHANES 数据库中符合特定标准的 23099 名参与者。使用 DII 指数四分位数建立基线。使用 Kaplan-Meier 曲线评估 DII 指数、WTI 指数、TyG 指数和 BMI 指数与 CKD 患者死亡率之间的关系。使用单变量和多变量 COX 回归风险模型研究 DII 指数、WTI 指数和 TyG 指数与 CKD 患者死亡风险的关系。对 eGFR 进行年龄和性别分层，以研究 DII 指数、WTI 指数和 TyG 指数与 CKD 患者死亡风险之间的关系。限制性立方样条分析用于研究 DII 指数、WTI 指数和 TyG 指数与 CKD 患者死亡风险之间的相关性。
随着 DII 指数、WTI 指数和 TyG 指数的升高，CKD 的发病率增加。经过多变量调整后，DII 指数、TyG 指数和 WTI 指数的四分位数显示出 CKD 的最高风险[DII：风险比（HR）1.36，95%置信区间（CI）（1.23-1.51）；TyG：HR 1.21；95% CI（1.07-1.37）；WTI：HR 1.29；95% CI（1.13-1.46）]。肥胖组（BMI≥24kg/m2）与正常体重组（P>0.05）相比，患 CKD 的风险无差异。
本研究表明，DII 指数、WTI 指数和 TyG 指数升高与 CKD 风险显著相关。此外，与其他指标相比，DII 指数在预测 CKD 方面具有更好的预后能力。
