Department of Clinical Laboratory Sciences, Faculty of Applied Medical Science, Taibah University, 344, Postal Code 3000, Al-Madinah, Saudi Arabia.
Mol Biol Rep. 2024 Nov 6;51(1):1123. doi: 10.1007/s11033-024-10072-z.
Type 2 diabetes mellitus (T2DM) is a growing global health concern. The pathogenesis of T2DM is multifactorial and intricate, involving a complex interplay of genetic predisposition, environmental factors, and molecular interactions. Vitamin D (circulating 25-hydroxyvitamin D concentration) regulates factors crucial for T2DM, including insulin secretion, sensitivity, and inflammation. Thus, vitamin D deficiency has been linked to poor health outcomes in T2DM patients. The cholesterol-synthesizing enzyme 7-dehydrocholesterol reductase (DHCR7) represents a critical regulatory switch between cholesterol and vitamin D3 synthesis. Recent findings suggest that the enzyme DHCR7 may indicate T2DM glycolipid metabolic disorder and is associated with deficient circulating vitamin D (circulating 25-hydroxyvitamin D concentration) status. In this PRISMA-guided systematic review, articles were sourced from two databases, namely, PubMed and Cochrane Library, to evaluate the impact of vitamin D deficiency in patients with T2DM and to explore the emerging role of DHCR7 in T2DM pathogenesis. Our findings strongly indicate a positive correlation between deficient vitamin D status and poor health outcomes in T2DM patients. Finally, this systematic review presents a novel perspective on T2DM development, focusing on the interplay between T2DM-associated hyperglycemia, expression of DHCR7, and abrogation of vitamin D synthesis.
2 型糖尿病（T2DM）是一个日益严重的全球健康问题。T2DM 的发病机制是多因素的，错综复杂的，涉及遗传易感性、环境因素和分子相互作用的复杂相互作用。维生素 D（循环 25-羟维生素 D 浓度）调节 T2DM 至关重要的因素，包括胰岛素分泌、敏感性和炎症。因此，维生素 D 缺乏与 T2DM 患者的不良健康结果有关。胆固醇合成酶 7-脱氢胆固醇还原酶（DHCR7）代表胆固醇和维生素 D3 合成之间的关键调节开关。最近的发现表明，该酶 DHCR7 可能表明 T2DM 糖脂代谢紊乱，并与循环维生素 D（循环 25-羟维生素 D 浓度）状态不足有关。在这项 PRISMA 指导的系统评价中，文章来源于两个数据库，即 PubMed 和 Cochrane Library，以评估维生素 D 缺乏症对 T2DM 患者的影响，并探讨 DHCR7 在 T2DM 发病机制中的新作用。我们的研究结果强烈表明，维生素 D 状态不足与 T2DM 患者的不良健康结果之间存在正相关。最后，本系统评价从一个新的角度探讨了 T2DM 的发展，重点关注与 T2DM 相关的高血糖、DHCR7 的表达以及维生素 D 合成的中断之间的相互作用。
