Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Department of Anatomy and Cell Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Sci Adv. 2024 Nov 8;10(45):eado1820. doi: 10.1126/sciadv.ado1820. Epub 2024 Nov 6.
Physiological needs evoke motivational drives that produce natural behaviors for survival. In previous studies, the temporally intertwined dynamics of need and motivation have made it challenging to differentiate these two components. On the basis of classic homeostatic theories, we established a normative framework to derive computational models for need-encoding and motivation-encoding neurons. By combining the model-based predictions and naturalistic experimental paradigms, we demonstrated that agouti-related peptide (AgRP) and lateral hypothalamic leptin receptor (LH neuronal activities encode need and motivation, respectively. Our model further explains the difference in the dynamics of appetitive behaviors induced by optogenetic stimulation of AgRP or LH neurons. Our study provides a normative modeling framework that explains how hypothalamic neurons separately encode need and motivation in the mammalian brain.
生理需求引发动机驱动，产生生存的自然行为。在以前的研究中，需求和动机的时间交织动态使得区分这两个成分具有挑战性。基于经典的动态平衡理论，我们建立了一个规范框架，推导出用于需求编码和动机编码神经元的计算模型。通过结合基于模型的预测和自然实验范式，我们证明了 AgRP 和外侧下丘脑瘦素受体（LH 神经元）的活动分别编码需求和动机。我们的模型进一步解释了光遗传学刺激 AgRP 或 LH 神经元引起的食欲行为动态的差异。我们的研究提供了一个规范的建模框架，解释了下丘脑神经元如何在哺乳动物大脑中分别编码需求和动机。
