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Clinical evaluation of the immunoadjuvant murabutide, a derivative of MDP, administered with a tetanus toxoid vaccine.

作者信息

Telzak E, Wolff S M, Dinarello C A, Conlon T, el Kholy A, Bahr G M, Choay J P, Morin A, Chedid L

出版信息

J Infect Dis. 1986 Mar;153(3):628-33. doi: 10.1093/infdis/153.3.628.

DOI:10.1093/infdis/153.3.628
PMID:3950444
Abstract
摘要

相似文献

1
Clinical evaluation of the immunoadjuvant murabutide, a derivative of MDP, administered with a tetanus toxoid vaccine.免疫佐剂 murabutide（一种 MDP 衍生物）与破伤风类毒素疫苗联合使用的临床评估。
J Infect Dis. 1986 Mar;153(3):628-33. doi: 10.1093/infdis/153.3.628.
2
Production of anti-sporozoite antibodies in absence of response to carrier by coupling an MDP derivative to a malaria peptide-tetanus toxoid conjugate.通过将一种MDP衍生物与疟疾肽-破伤风类毒素偶联物结合，在对载体无反应的情况下产生抗子孢子抗体。
Biochem Biophys Res Commun. 1985 Aug 30;131(1):70-6. doi: 10.1016/0006-291x(85)91771-1.
3
Biologically active antibodies elicited by a synthetic circumsporozoite peptide of Plasmodium knowlesi administered in saline with a muramyl dipeptide derivative.由诺氏疟原虫合成环子孢子肽与一种胞壁酰二肽衍生物在盐水中混合给药所引发的生物活性抗体。
Infect Immun. 1985 Jun;48(3):839-42. doi: 10.1128/iai.48.3.839-842.1985.
4
Role of muramyl peptides for the enhancement of synthetic vaccines.胞壁酰肽在增强合成疫苗方面的作用。
Dev Biol Stand. 1986;63:133-40.
5
Comparison of immunomodulatory activities in mice and guinea pigs of a synthetic desmuramyl peptidolipid triglymyc.合成去 muramyl 肽脂 Triglymyc 在小鼠和豚鼠体内免疫调节活性的比较。
Infect Immun. 1984 Mar;43(3):870-5. doi: 10.1128/iai.43.3.870-875.1984.
6
Formulation of a potential antipregnancy vaccine based on the beta-subunit of human chorionic gonadotropin (beta-hCG). II. Use of compounds of the muramyl dipeptide (MDP) family as adjuvants.基于人绒毛膜促性腺激素β亚基（β-hCG）的潜在抗妊娠疫苗的研制。II. 胞壁酰二肽（MDP）家族化合物作为佐剂的应用。
J Reprod Immunol. 1985 Feb;7(2):151-62. doi: 10.1016/0165-0378(85)90069-5.
7
Enhancement by murabutide of the immune response to natural and synthetic hepatitis B surface antigens.莫拉司亭对天然和合成乙肝表面抗原免疫反应的增强作用。
Infect Immun. 1984 Jul;45(1):261-6. doi: 10.1128/iai.45.1.261-266.1984.
8
Enhancement of immunoglobulin G responses in mice against hepatitis B virus surface antigen, influenza virus hemagglutinin vaccine, and tetanus toxoid by 6-O-acylated muramyl dipeptides.6-O-酰化的胞壁酰二肽增强小鼠对乙型肝炎病毒表面抗原、流感病毒血凝素疫苗和破伤风类毒素的免疫球蛋白G反应。
Infect Immun. 1989 Jun;57(6):1839-44. doi: 10.1128/iai.57.6.1839-1844.1989.
9
A potential anti-pregnancy vaccine built by conjugation of the beta-subunit of human chorionic gonadotropin to adjuvant-active muramyl peptide.一种通过将人绒毛膜促性腺激素的β亚基与具有佐剂活性的胞壁酰肽偶联构建的潜在抗妊娠疫苗。
Am J Reprod Immunol Microbiol. 1987 Jul;14(3):84-90. doi: 10.1111/j.1600-0897.1987.tb00125.x.
10
Enhancement of serum antibody production in mice by oral administration of lipophilic derivatives of muramyl peptides and bacterial lipopolysaccharides with bovine serum albumin.通过口服给予带有牛血清白蛋白的胞壁酰肽和亲脂性衍生物以及细菌脂多糖增强小鼠血清抗体产生。
Methods Find Exp Clin Pharmacol. 1986 Feb;8(2):117-25.

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Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation.新发疾病时代的合理疫苗设计：保护的免疫相关指标、疫苗抗原及免疫调节的关键抉择
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Harnessing the untapped potential of nucleotide-binding oligomerization domain ligands for cancer immunotherapy.
利用核苷酸结合寡聚化结构域配体挖掘癌症免疫治疗的潜力。
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Sci Rep. 2017 Dec 12;7(1):17429. doi: 10.1038/s41598-017-17653-y.
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Advax-adjuvanted recombinant protective antigen provides protection against inhalational anthrax that is further enhanced by addition of murabutide adjuvant.Advax佐剂重组保护性抗原可提供针对吸入性炭疽的保护作用，添加murabutide佐剂可进一步增强这种保护作用。
Clin Vaccine Immunol. 2014 Apr;21(4):580-6. doi: 10.1128/CVI.00019-14. Epub 2014 Feb 19.
6
Intranasal vaccination with murabutide enhances humoral and mucosal immune responses to a virus-like particle vaccine.鼻腔内接种 murabutide 可增强针对病毒样颗粒疫苗的体液和黏膜免疫应答。
PLoS One. 2012;7(7):e41529. doi: 10.1371/journal.pone.0041529. Epub 2012 Jul 25.
7
The transcriptional response of human macrophages to murabutide reflects a spectrum of biological effects for the synthetic immunomodulator.人类巨噬细胞对murabutide的转录反应反映了这种合成免疫调节剂的一系列生物学效应。
Clin Exp Immunol. 2002 Jun;128(3):474-82. doi: 10.1046/j.1365-2249.2002.01872.x.
8
Enhanced maturation and functional capacity of monocyte-derived immature dendritic cells by the synthetic immunomodulator Murabutide.合成免疫调节剂Murabutide增强单核细胞来源的未成熟树突状细胞的成熟和功能能力。
Immunology. 2001 Aug;103(4):479-87. doi: 10.1046/j.1365-2567.2001.01269.x.
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Selective regulation of human immunodeficiency virus-infected CD4(+) lymphocytes by a synthetic immunomodulator leads to potent virus suppression in vitro and in hu-PBL-SCID mice.一种合成免疫调节剂对人类免疫缺陷病毒感染的CD4(+)淋巴细胞的选择性调节导致体外和人外周血淋巴细胞-严重联合免疫缺陷小鼠体内有效的病毒抑制。
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The synthetic immunomodulator murabutide controls human immunodeficiency virus type 1 replication at multiple levels in macrophages and dendritic cells.合成免疫调节剂莫拉司亭在巨噬细胞和树突状细胞的多个水平上控制1型人类免疫缺陷病毒的复制。
J Virol. 2000 Sep;74(17):7794-802. doi: 10.1128/jvi.74.17.7794-7802.2000.