van der Geest Rick, Lee Janet S
Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, 3459 Fifth Avenue, Pittsburgh, PA 15213, United States.
Vascular Medicine Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, United States.
J Leukoc Biol. 2025 Mar 14;117(3). doi: 10.1093/jleuko/qiae245.
BATF2 is a transcription factor known to exhibit tumor-suppressive activity in cancer cells. Within recent years, however, BATF2 has also emerged as an important transcriptional regulator of the immune system. Through its immunomodulatory function, BATF2 has been implicated in a variety of (patho)physiological processes, including host defense against infection, antitumor immunity, and maintenance of tissue inflammatory homeostasis. Below, we discuss recent literature that has provided insight into the role of BATF2 as a transcriptional regulator of immune responses in health and disease, including the cell types that express BATF2, the different diseases in which the immunomodulatory effects of BATF2 have been shown to play a role, and the molecular mechanisms through which BATF2 is thought to exert those effects. In doing so, we highlight that the immunological effects of BATF2 are highly context dependent, and we point out the overlap between the mechanisms of action of BATF2 in infectious and noninfectious diseases. We also discuss areas of interest for future research, the clinical relevance of better understanding BATF2 function, and potential strategies for therapeutic modulation of BATF2.
BATF2是一种已知在癌细胞中具有肿瘤抑制活性的转录因子。然而，近年来，BATF2也已成为免疫系统的一种重要转录调节因子。通过其免疫调节功能，BATF2参与了多种（病理）生理过程，包括宿主抗感染防御、抗肿瘤免疫以及维持组织炎症稳态。下面，我们讨论最近的文献，这些文献深入探讨了BATF2作为健康和疾病中免疫反应转录调节因子的作用，包括表达BATF2的细胞类型、已证明BATF2的免疫调节作用发挥作用的不同疾病，以及BATF2被认为发挥这些作用的分子机制。在此过程中，我们强调BATF2的免疫效应高度依赖于背景，并指出BATF2在感染性和非感染性疾病中的作用机制之间的重叠。我们还讨论了未来研究的感兴趣领域、更好地理解BATF2功能的临床相关性以及BATF2治疗调节的潜在策略。
