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减少可卡因使用对免疫功能标志物的影响。

Influence of cocaine use reduction on markers of immune function.

作者信息

Stoops William W, Shellenberg Thomas P, Regnier Sean D, Cox David H, Adatorwovor Reuben, Hays Lon R, Anderson Danielle M, Lile Joshua A, Schmitz Joy M, Havens Jennifer R, Segerstrom Suzanne C

机构信息

Department of Behavioral Science, University of Kentucky College of Medicine, 1100 Veterans Drive, Medical Behavioral Science Building, Lexington, KY 40536-0086, USA; Department of Psychiatry, University of Kentucky College of Medicine, 245 Fountain Court, Lexington, KY 40509-1810, USA; Department of Psychology, University of Kentucky College of Arts and Sciences, 171 Funkhouser Drive, Lexington, KY 40506-0044, USA; Center on Drug and Alcohol Research, University of Kentucky College of Medicine, 845 Angliana Ave, Lexington, KY 40508, USA.

Department of Behavioral Science, University of Kentucky College of Medicine, 1100 Veterans Drive, Medical Behavioral Science Building, Lexington, KY 40536-0086, USA; Department of Psychology, University of Kentucky College of Arts and Sciences, 171 Funkhouser Drive, Lexington, KY 40506-0044, USA.

出版信息

J Neuroimmunol. 2024 Dec 15;397:578470. doi: 10.1016/j.jneuroim.2024.578470. Epub 2024 Oct 28.

DOI:10.1016/j.jneuroim.2024.578470
PMID:39504756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11620913/
Abstract

This study determined the effects of reduced cocaine use on immune function. Treatment seeking participants with Cocaine Use Disorder enrolled in a 12-week contingency management trial to reduce cocaine use. Participants were randomly assigned 1:1:1 to High Value Reinforcers (i.e., $55/negative urine sample) for cocaine abstinence (n = 41), Low Value Reinforcers (i.e., $13/negative urine sample) for cocaine abstinence (n = 33) or Non-Contingent Control (n = 33). Immune measures were collected at 6-week intervals. The High Value group had greatest use reductions, increased erythema and IL-6 and decreased IL-10 and CCL5, suggesting an activated immune response. Cocaine use reduction may promote changes in immune health.

摘要

本研究确定了减少可卡因使用对免疫功能的影响。寻求治疗的可卡因使用障碍参与者参加了一项为期12周的应急管理试验，以减少可卡因使用。参与者被随机按1:1:1分配到用于可卡因戒断的高价值强化物组（即每次阴性尿液样本奖励55美元）（n = 41）、用于可卡因戒断的低价值强化物组（即每次阴性尿液样本奖励13美元）（n = 33）或非应急对照组（n = 33）。每隔6周收集免疫指标。高价值组的使用减少最多，红斑和白细胞介素-6增加，白细胞介素-10和趋化因子配体5减少，提示免疫反应激活。减少可卡因使用可能会促进免疫健康的变化。

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Reduced drug use as an alternative valid outcome in individuals with stimulant use disorders: Findings from 13 multisite randomized clinical trials.减少药物使用作为兴奋剂使用障碍个体的另一种有效结局：来自 13 个多中心随机临床试验的结果。
Addiction. 2024 May;119(5):833-843. doi: 10.1111/add.16409. Epub 2024 Jan 10.
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Dysregulation of immunity by cigarette smoking promotes inflammation and cancer: A review.
吸烟引起的免疫失调促进炎症和癌症：综述。
Environ Pollut. 2023 Dec 15;339:122730. doi: 10.1016/j.envpol.2023.122730. Epub 2023 Oct 12.
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Stimulant use, HIV, and immune dysregulation among sexual minority men.性少数男性中的兴奋剂使用、HIV 和免疫失调。
Drug Alcohol Depend. 2023 Oct 1;251:110942. doi: 10.1016/j.drugalcdep.2023.110942. Epub 2023 Aug 23.
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Circadian disruption and psychostimulants dysregulates plasma acute-phase proteins and circulating cell-free mitochondrial DNA.昼夜节律紊乱和精神兴奋剂会使血浆急性期蛋白和循环游离线粒体DNA失调。
Brain Behav Immun Health. 2023 Jun 27;31:100659. doi: 10.1016/j.bbih.2023.100659. eCollection 2023 Aug.
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Drug Alcohol Depend. 2023 Jul 1;248:109947. doi: 10.1016/j.drugalcdep.2023.109947. Epub 2023 May 26.
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Cocaine-use disorder and childhood maltreatment are associated with the activation of neutrophils and increased inflammation.可卡因使用障碍和童年期受虐与中性粒细胞的激活及炎症增加有关。
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