GPR56：GPCR 作为铁死亡的守护者。
GPR56: GPCR as a guardian against ferroptosis.
机构信息
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
出版信息
Cell Metab. 2024 Nov 5;36(11):2355-2356. doi: 10.1016/j.cmet.2024.08.011.
Transmembrane receptor proteins are proficient in sensing external signals and initiating downstream pathways to control cell survival. Lin et al. demonstrated that GPR56, a G-protein-coupled receptor, can be activated by its agonist to suppress ferroptosis-a form of cell death-and effectively mitigate ferroptosis-associated liver damage.
跨膜受体蛋白在感知外部信号并启动下游途径以控制细胞存活方面表现出色。Lin 等人表明，G 蛋白偶联受体 GPR56 可以被其激动剂激活，从而抑制细胞死亡的一种形式——铁死亡，并有效减轻铁死亡相关的肝损伤。
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