Yang Lan, Ling Zhengjia, Yao Di, Su Jingna, He Shufeng, Zhou Xiaopei, Gu Ying
Prenatal Diagnosis Center, Wuxi Maternal and Child Health Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, China.
J Obstet Gynaecol Res. 2025 Jan;51(1):e16143. doi: 10.1111/jog.16143. Epub 2024 Nov 6.
There is limited and conflicting evidence available regarding the correlation between maternal vitamin D status and childhood overweight and body mass index (BMI). The aim of this study was to investigate the following: (1) potential association between maternal 25-hydroxyvitamin D (25(OH)D) levels and newborn growth status; (2) relationship between maternal 25OHD levels and BMI and the risk of overweight with preschoolers being overweight.
A cohort of 3213 eligible singleton mother-infant pairs were used to investigate the possible associations between maternal 25(OH)D levels and fetal growth status. Data of 1767 available singleton mother-infant pairs and 6-year-old preschoolers was applied to analyze the potential correlations between maternal 25(OH)D status and risk of childhood overweight.
Compared with sufficient 25(OH)D in pregnancy group (≥75 nmol/L), there were no correlations between the maternal 25(OH)D deficiency (<50 nmol/L) and large gestational age (LGA) (p = 0.465), small gestational age (SGA) (p = 0.607), lower birth weight (LBW) (p = 0.725) or fetal macrosomia (p = 0.535). Moreover, no significant associations between insufficient maternal 25(OH)D (50-75 nmol/L) and LGA (p = 0.505), SGA (p = 0.816), LBW (p = 0.816), or fetal macrosomia (p = 0.413) were observed. We found statistically significant disparities between the fetal birth weight and height (p < 0.001), weight (p < 0.001), head circumference (p = 0.001) of 6-years preschooler. No significant associations were found between the maternal 25(OH)D levels and BMI and risk of overweight at 6-year-old preschoolers.
There were no apparent correlation found between maternal 25(OH)D concentrations and fetal birth status. There was no evidence found to suggest the effect of maternal 25(OH)D level on overweight at 6-year-old preschoolers.
关于母亲维生素D状态与儿童超重及体重指数（BMI）之间的相关性，现有证据有限且相互矛盾。本研究的目的是调查以下内容：（1）母亲25-羟基维生素D（25(OH)D）水平与新生儿生长状况之间的潜在关联；（2）母亲25OHD水平与BMI以及学龄前儿童超重风险之间的关系。
采用3213对符合条件的单胎母婴队列，调查母亲25(OH)D水平与胎儿生长状况之间的可能关联。应用1767对可获得的单胎母婴及6岁学龄前儿童的数据，分析母亲25(OH)D状态与儿童超重风险之间的潜在相关性。
与孕期25(OH)D充足组（≥75 nmol/L）相比，母亲25(OH)D缺乏（<50 nmol/L）与大孕周（LGA）（p = 0.465）、小孕周（SGA）（p = 0.607）、低出生体重（LBW）（p = 0.725）或巨大儿（p = 0.535）之间均无相关性。此外，未观察到母亲25(OH)D不足（50 - 75 nmol/L）与LGA（p = 0.505）、SGA（p = 0.816）、LBW（p = 0.816）或巨大儿（p = 0.413）之间存在显著关联。我们发现6岁学龄前儿童的出生体重与身高（p < 0.001）、体重（p < 0.001）、头围（p = 0.001）之间存在统计学显著差异。未发现母亲25(OH)D水平与6岁学龄前儿童的BMI及超重风险之间存在显著关联。
未发现母亲25(OH)D浓度与胎儿出生状况之间存在明显相关性。没有证据表明母亲25(OH)D水平对6岁学龄前儿童超重有影响。
