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Cobb角超过20°的腰椎管狭窄症患者的短节段融合与单纯减压治疗对比

Short-segment fusion versus isolated decompression in lumbar spinal canal stenosis patients with Cobb angles over 20°.

作者信息

Asada Tomoyuki, Simon Chad Z, Durbas Atahan, Allen Myles R J, DiSilvestro Kevin J, Hirase Takashi, Singh Nishtha, Bovonratwet Patawut, Bay Annika, Subramanian Tejas, Mai Eric, Kim Yeo Eun, Korsun Maximillian K, Tuma Olivia C, Araghi Kasra, Zhang Joshua, Kim Eric T, Kwas Cole T, Lu Amy Z, Vaishnav Avani S, Dowdell James E, Sheha Evan D, Qureshi Sheeraz A, Iyer Sravisht

机构信息

Hospital for Special Surgery, 535 E 70th St, New York, NY, USA.

Hospital for Special Surgery, 535 E 70th St, New York, NY, USA; Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA.

出版信息

Spine J. 2025 Apr;25(4):669-678. doi: 10.1016/j.spinee.2024.10.007. Epub 2024 Nov 4.

Abstract

BACKGROUND CONTEXT

Lumbar decompression and short-segment lumbar fusion are standard procedures for short-segment lumbar canal stenosis, even in patients with moderate Cobb angles. Adult degenerative scoliosis is diagnosed at a threshold of 10°, and patients with coronal Cobb angles over 30° are recommended for long fusion due to global spinal deformity. However, there is a lack of research on clinical outcomes in patients with moderate coronal deformity, such as Cobb angles between 20° and 30°.

PURPOSE

This study aims to investigate the radiographic and clinical outcome differences between isolated decompression and short-segment interbody fusion for lumbar spinal canal stenosis in patients with moderate coronal deformity.

STUDY DESIGN

A retrospective analysis of a prospectively collected registry.

PATIENT SAMPLE

Patients with Cobb angle exceeding 20° who underwent 1- or 2- levels of lumbar surgery for lumbar canal stenosis. Patients diagnosed as spinal deformity were excluded.

OUTCOME MEASURES

Patient-reported outcomes included Oswestry Disability Index (ODI), VAS back, VAS leg, Short form 12 physical component score (SF-12 PCS) and Mental Component Score (SF-12 MCS), and patient-reported outcomes measurement information system physical function (PROMIS-PF) at preoperative, 12-week postoperative, and 1-year postoperative timepoints. Preoperative and postoperative spinopelvic alignment was assessed using Cobb angle, pelvic tilt, sacral slope, pelvic incidence, lumbar lordosis and PI minus LL.

METHODS

A propensity score-matched analysis with the overlap weighting was utilized to investigate patient-reported outcomes at 12-week and 1-year postoperatively between the surgery groups. Spinopelvic alignments were compared between preoperative and 1-year postoperative timepoint using a linear mixed-effect model.

RESULTS

Before overlap weighting, the two surgery groups showed significant differences in age and diagnosis. No obvious sagittal malalignment was observed (PI minus LL: decompression, 7.4° vs fusion, 11.5°). After propensity score weighting, the fusion groups exhibited significantly better ODI and VAS back at the 1-year timepoint (ODI: fusion, 16.6 vs decompression, 28.1, p=.013; VAS back: fusion, 1.5±2.1 vs decompression, 3.7±1.9, p<.001). Radiographic assessment showed that the fusion group achieved better PI minus LL compared to decompression group (15° vs 10°, p=.008).

CONCLUSION

In patients with degenerative scoliosis and a Cobb angle greater than 20°, short-segment lumbar fusion surgery may result in enhanced improvement for short-segment lumbar pathology compared to isolated decompression.

摘要

背景

腰椎减压和短节段腰椎融合术是治疗短节段腰椎管狭窄的标准术式,即使是对于Cobb角中度的患者。成人退变性脊柱侧凸的诊断阈值为10°,对于冠状面Cobb角超过30°的患者,由于存在整体脊柱畸形,建议进行长节段融合。然而,对于冠状面畸形中度(如Cobb角在20°至30°之间)的患者的临床疗效缺乏研究。

目的

本研究旨在探讨中度冠状面畸形的腰椎管狭窄患者单纯减压与短节段椎间融合术后影像学和临床疗效的差异。

研究设计

对前瞻性收集的登记资料进行回顾性分析。

患者样本

Cobb角超过20°且因腰椎管狭窄接受1或2节段腰椎手术的患者。排除诊断为脊柱畸形的患者。

观察指标

患者报告的结局包括Oswestry功能障碍指数(ODI)、腰部视觉模拟评分(VAS back)、腿部视觉模拟评分(VAS leg)、简明健康调查12项身体成分评分(SF - 12 PCS)和精神成分评分(SF - 12 MCS),以及术前、术后12周和术后1年的患者报告结局测量信息系统身体功能(PROMIS - PF)。术前和术后使用Cobb角、骨盆倾斜度、骶骨倾斜度、骨盆入射角、腰椎前凸和骨盆入射角减去腰椎前凸来评估矢状面骨盆对线情况。

方法

采用倾向得分匹配分析和重叠加权法来研究手术组术后12周和1年的患者报告结局。使用线性混合效应模型比较术前和术后1年时间点的矢状面骨盆对线情况。

结果

在重叠加权前,两个手术组在年龄和诊断方面存在显著差异。未观察到明显的矢状面失对线(骨盆入射角减去腰椎前凸:减压组为7.4°,融合组为11.5°)。倾向得分加权后,融合组在术后1年时ODI和腰部VAS评分显著更好(ODI:融合组为16.6,减压组为

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