Keerthiga Rajendiran, Xie Yafang, Pei De-Sheng, Fu Ailing
College of Pharmaceutical Science, Southwest University, Chongqing, 400716, China; Department of Computational Biology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Thandalam, Chennai 602105, Tamil Nadu, India.
College of Pharmaceutical Science, Southwest University, Chongqing, 400716, China.
Mitochondrion. 2025 Jan;80:101977. doi: 10.1016/j.mito.2024.101977. Epub 2024 Nov 4.
Changes in mitochondrial metabolism produce a malignant transformation from normal cells to tumor cells. Mitochondrial metabolism, comprising bioenergetic metabolism, biosynthetic process, biomolecular decomposition, and metabolic signal conversion, obviously forms a unique sign in the process of tumorigenesis. Several oncometabolites produced by mitochondrial metabolism maintain tumor phenotype, which are recognized as tumor indicators. The mitochondrial metabolism synchronizes the metabolic and genetic outcome to the potent tumor microenvironmental signals, thereby further promoting tumor initiation. Moreover, the bioenergetic and biosynthetic metabolism within tumor mitochondria orchestrates dynamic contributions toward cancer progression and invasion. In this review, we describe the contribution of mitochondrial metabolism in tumorigenesis through shaping several hallmarks such as microenvironment modulation, plasticity, mitochondrial calcium, mitochondrial dynamics, and epithelial-mesenchymal transition. The review will provide a new insight into the abnormal mitochondrial metabolism in tumorigenesis, which will be conducive to tumor prevention and therapy through targeting tumor mitochondria.
线粒体代谢的变化会导致正常细胞向肿瘤细胞的恶性转化。线粒体代谢包括生物能量代谢、生物合成过程、生物分子分解和代谢信号转换，在肿瘤发生过程中明显形成独特特征。线粒体代谢产生的几种肿瘤代谢物维持肿瘤表型，被视为肿瘤标志物。线粒体代谢将代谢和遗传结果与强大的肿瘤微环境信号同步，从而进一步促进肿瘤起始。此外，肿瘤线粒体中的生物能量和生物合成代谢对癌症进展和侵袭起着动态作用。在本综述中，我们通过塑造微环境调节、可塑性、线粒体钙、线粒体动力学和上皮-间质转化等多个特征来描述线粒体代谢在肿瘤发生中的作用。该综述将为肿瘤发生中线粒体代谢异常提供新的见解，这将有助于通过靶向肿瘤线粒体进行肿瘤预防和治疗。
