Yao C, Li W, Pang R, Zhou J
Department of Orthopedics and Traumatology, Shenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China.
Department of Pulmonary and Critical Care Medicine, Shenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2024 Sep 20;44(9):1821-1830. doi: 10.12122/j.issn.1673-4254.2024.09.23.
To analyze the causal relationship of gluteal tendinitis and primary coxarthrosis with the occurrence of iliotibial band syndrome using Mendelian randomization.
The GWAS data of gluteal tendinitis, primary coxarthrosis and iliotibial band syndrome were screened for high correlation single-nucleotide polymorphisms (SNPs). Mendelian randomization analysis was performed using random-effects inverse variance weighting (IVW), MR-Egger regression, and weighted median method to determine whether gluteal tendinitis and primary coxarthrosis were causally related with iliotibial band syndrome. Heterogeneity test, multiple validity test and sensitivity analysis, and clinical data analysis were used to verify the reliability of the results.
Both gluteal tendinitis [IVW: OR(95% )=1.32 (1.03-1.68), =0.026] and primary coxarthrosis [IVW: OR (95% )=1.40 (1.06-1.84), =0.017] was positively correlated with iliotibial band syndrome.
Gluteal tendinitis and primary coxarthrosis may increase the risk of iliotibial band syndrome.
采用孟德尔随机化方法分析臀肌肌腱炎和原发性髋关节炎与髂胫束综合征发生之间的因果关系。
筛选臀肌肌腱炎、原发性髋关节炎和髂胫束综合征的全基因组关联研究（GWAS）数据中的高度相关单核苷酸多态性（SNP）。使用随机效应逆方差加权法（IVW）、MR-Egger回归法和加权中位数法进行孟德尔随机化分析，以确定臀肌肌腱炎和原发性髋关节炎与髂胫束综合征是否存在因果关系。采用异质性检验、多种效度检验和敏感性分析以及临床数据分析来验证结果的可靠性。
臀肌肌腱炎[IVW：比值比（95%）=1.32（1.03-1.68），P=0.026]和原发性髋关节炎[IVW：比值比（95%）=1.40（1.06-1.84），P=0.017]均与髂胫束综合征呈正相关。
臀肌肌腱炎和原发性髋关节炎可能会增加髂胫束综合征的风险。
