[关于视网膜母细胞瘤起源与发病机制的思考]

[Reflection on the origin and pathogenesis of retinoblastoma].

作者信息

Jin Z B, Xu J, Li B

机构信息

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2024 Nov 11;60(11):883-886. doi: 10.3760/cma.j.cn112142-20240724-00316.

DOI:10.3760/cma.j.cn112142-20240724-00316

PMID:39505372

Abstract

Retinoblastoma, one of the most common intraocular malignancies in infants and young children, seriously affects the vision and life. The in-depth study of the origin and pathogenesis of retinoblastoma, which remain controversial, is crucial. This article summarizes the research progress on the cell origin of retinoblastoma and the second hit theory, aiming to provide a theoretical basis for the diagnosis, treatment, and prevention of retinoblastoma.

摘要

视网膜母细胞瘤是婴幼儿最常见的眼内恶性肿瘤之一，严重影响视力和生命。对视网膜母细胞瘤起源和发病机制的深入研究至关重要，但其仍存在争议。本文综述了视网膜母细胞瘤细胞起源及二次打击理论的研究进展，旨在为视网膜母细胞瘤的诊断、治疗及预防提供理论依据。