Center for Cell Analysis and Modeling, University of Connecticut, Farmington, Connecticut 06030, USA.
Center for Cell Analysis and Modeling, University of Connecticut, Farmington, Connecticut 06030, USA
Genes Dev. 2024 Nov 27;38(21-24):931-932. doi: 10.1101/gad.352340.124.
Notch signaling is a highly conserved pathway activated by dynamic cellular interactions that initiates a molecular cascade that ultimately drives changes in gene expression. The Notch transcriptional complex (NTC) regulates genes that influence development and homeostasis. In this issue of , Rogers and colleagues (doi:10.1101/gad.352108.124) leverage a rapid Notch activation system combined with molecular genomic profiling to reveal that the NTC regulates the release of paused RNA polymerase to activate direct target genes. They also highlight the role of the SWI/SNF chromatin remodeling complex in establishing and maintaining chromatin accessibility to potentiate the activation of NTC target genes.
Notch 信号通路是一种高度保守的途径，通过动态的细胞相互作用激活，引发分子级联反应，最终导致基因表达的改变。Notch 转录复合物（NTC）调节影响发育和内稳态的基因。在本期的《基因与发育》杂志中，Rogers 及其同事（doi:10.1101/gad.352108.124）利用一种快速 Notch 激活系统结合分子基因组谱分析，揭示了 NTC 调节暂停 RNA 聚合酶的释放以激活直接靶基因。他们还强调了 SWI/SNF 染色质重塑复合物在建立和维持染色质可及性以增强 NTC 靶基因激活中的作用。
