FROM, Fondazione per la Ricerca Ospedale di Bergamo ETS, Bergamo, Italy.
Dipartimento di Scienze Mediche e Chirurgiche, Materno-Infantili e dell'Adulto, Università di Modena-Reggio Emilia, Modena, Italy.
Blood Cancer J. 2024 Nov 6;14(1):195. doi: 10.1038/s41408-024-01176-7.
We analyzed the neutrophil-to-lymphocyte ratio (NLR) in 1508 patients with PV and found that those with an NLR ≥ 5 were generally older, had a longer disease history, and had higher cardiovascular risk factors, more arterial thrombosis, and more aggressive blood counts, indicating a more proliferative disease. NLR was an accurate predictor of mortality, with patients with NLR ≥ 5 having significantly worse overall survival and more than twice the mortality rate compared to those with NLR < 5. Multivariable models confirmed that increasing age, previous venous thrombosis and NLR ≥ 5 were strong predictors of death, further influenced by cardiovascular risk factors. We examined the interaction between NLR and the number of cardiovascular risk factors and found a progressive trend of increased mortality risk for NLR values ≥ 5 in addition to the presence of more than one risk factor. In conclusion, patients with NLR ≥ 5 require careful monitoring and management of cardiovascular risk factors because they increase mortality when associated with progressive levels of NLR.
我们分析了 1508 例 PV 患者的中性粒细胞与淋巴细胞比值（NLR），发现 NLR≥5 的患者通常年龄较大，疾病史较长，心血管危险因素较高，动脉血栓形成较多，血液计数更具侵袭性，表明疾病更具增生性。NLR 是死亡率的准确预测指标，NLR≥5 的患者总生存率明显较差，死亡率是 NLR<5 的患者的两倍多。多变量模型证实，年龄增长、既往静脉血栓形成和 NLR≥5 是死亡的强烈预测因素，进一步受心血管危险因素的影响。我们检查了 NLR 与心血管危险因素数量之间的相互作用，发现 NLR 值≥5 除了存在一个以上危险因素外，与死亡率风险增加呈正相关。总之，NLR≥5 的患者需要仔细监测和管理心血管危险因素，因为它们与 NLR 的逐渐升高水平相关联会增加死亡率。
