对于老年急性髓系白血病患者，造血细胞移植后的生存与移植前疾病负担相关，而非年龄或供体类型。 - Suppr

Pre-transplant disease burden rather than age or donor type was associated with survival of hematopoietic cell transplantation for elderly patients with acute myeloid leukemia.

作者信息

Ma Rui, Liao Yi, Zhang Xiao-Hui, Xu Lan-Ping, Wang Yu, Mo Xiao-Dong, Lv Meng, Zhang Yuan-Yuan, Yan Chen-Hua, Chen Yu-Hong, Chen Yao, Wang Jing-Zhi, Wang Feng-Rong, Han Ting-Ting, Wang Zhi-Dong, Han Wei, Chen Huan, He Yun, Xu Zheng-Li, Zheng Feng-Mei, Fu Hai-Xia, Liu Kai-Yan, Huang Xiao-Jun, Sun Yu-Qian

机构信息

Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Treatment of Hematological Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation for the Treatment of Hematological Diseases, Beijing, China.

Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

出版信息

Bone Marrow Transplant. 2025 Jan;60(1):107-109. doi: 10.1038/s41409-024-02457-2. Epub 2024 Nov 6.

DOI:10.1038/s41409-024-02457-2

PMID:39506074

Abstract

摘要

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Pre-transplant disease burden rather than age or donor type was associated with survival of hematopoietic cell transplantation for elderly patients with acute myeloid leukemia.对于老年急性髓系白血病患者，造血细胞移植后的生存与移植前疾病负担相关，而非年龄或供体类型。

Bone Marrow Transplant. 2025 Jan;60(1):107-109. doi: 10.1038/s41409-024-02457-2. Epub 2024 Nov 6.

Comparable Outcomes After Alternative and Matched Sibling Donor Hematopoietic Stem Cell Transplantation and the Role of Molecular Measurable Residual Disease for Acute Myeloid Leukemia in Elderly Patients.老年急性髓系白血病患者采用不同供者来源造血干细胞移植及分子可测残留病对其预后的影响

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Haematologica. 2018 Aug;103(8):1317-1328. doi: 10.3324/haematol.2018.189258. Epub 2018 May 10.

Allogenic hematopoietic stem cell transplantation outcomes of patients aged ≥ 55 years with acute myeloid leukemia or myelodysplastic syndromes in China: a retrospective study.中国≥55 岁急性髓系白血病或骨髓增生异常综合征患者异基因造血干细胞移植的结果：一项回顾性研究。

Stem Cell Res Ther. 2024 Jan 29;15(1):24. doi: 10.1186/s13287-024-03640-4.

Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome.老年急性髓系白血病或骨髓增生异常综合征患者采用亲缘单倍体造血干细胞移植联合移植后环磷酰胺和外周血造血干细胞移植。

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Analysis of non-HLA genomic risk factors in HLA-matched unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia.分析 HLA 匹配的无关供者造血细胞移植治疗慢性髓细胞白血病的非 HLA 基因组风险因素。

Haematologica. 2012 Jul;97(7):1014-9. doi: 10.3324/haematol.2011.053611. Epub 2012 Jan 22.

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Comparison of matched sibling donors versus unrelated donors in allogeneic stem cell transplantation for primary refractory acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT.原发性难治性急性髓系白血病异基因造血干细胞移植中匹配同胞供者与无关供者的比较：一项代表 EBMT 急性白血病工作组进行的研究。

J Hematol Oncol. 2017 Jun 24;10(1):130. doi: 10.1186/s13045-017-0498-8.

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Cancer Med. 2020 Sep;9(17):6244-6255. doi: 10.1002/cam4.3290. Epub 2020 Jul 20.

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Front Immunol. 2025 Jul 4;16:1586523. doi: 10.3389/fimmu.2025.1586523. eCollection 2025.

Divergent prognostic factors in high-risk vs. standard-risk patients aged 50-65 years after allo-HCT for AML/MDS: a single-center retrospective analysis.急性髓系白血病/骨髓增生异常综合征异基因造血干细胞移植后50-65岁高危与标准风险患者的不同预后因素：一项单中心回顾性分析

Bone Marrow Transplant. 2025 May 8. doi: 10.1038/s41409-025-02619-w.

本文引用的文献

Alternative donor BMT with posttransplant cyclophosphamide as initial therapy for acquired severe aplastic anemia.异基因造血干细胞移植联合移植后环磷酰胺治疗获得性重型再生障碍性贫血。

Blood. 2023 Jun 22;141(25):3031-3038. doi: 10.1182/blood.2023020435.

Acute myeloid leukaemia.急性髓细胞白血病。

Lancet. 2023 Jun 17;401(10393):2073-2086. doi: 10.1016/S0140-6736(23)00108-3. Epub 2023 Apr 15.

An 8-year pragmatic observation evaluation of the benefits of allogeneic HCT in older and medically infirm patients with AML.对老年及身体虚弱的急性髓系白血病患者进行异基因造血细胞移植益处的8年实用性观察评估。

Blood. 2023 Jan 19;141(3):295-308. doi: 10.1182/blood.2022016916.

Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.成人 AML 的诊断与治疗：ELN 专家组代表发布的 2022 年国际专家建议

Blood. 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867.

GITMO Registry Study on Allogeneic Transplantation in Patients Aged ≥60 Years from 2000 to 2017: Improvements and Criticisms.2000年至2017年GITMO关于≥60岁患者同种异体移植的登记研究：进展与批评

Transplant Cell Ther. 2022 Feb;28(2):96.e1-96.e11. doi: 10.1016/j.jtct.2021.11.006. Epub 2021 Nov 21.

Summary of Scientific and Statistical Methods, Study Endpoints and Definitions for Observational and Registry-Based Studies in Hematopoietic Cell Transplantation.造血细胞移植中基于观察性研究和注册研究的科学与统计方法、研究终点及定义总结

Clin Hematol Int. 2019 Dec 17;2(1):2-4. doi: 10.2991/chi.d.191207.001. eCollection 2020 Mar.

Is outcome of older people with acute myeloid leukemia improving with new therapeutic approaches and stem cell transplantation?新的治疗方法和干细胞移植是否改善了老年急性髓系白血病患者的预后？

Expert Rev Hematol. 2020 Feb;13(2):99-108. doi: 10.1080/17474086.2020.1715207. Epub 2020 Jan 22.

Haploidentical transplantation might have superior graft-versus-leukemia effect than HLA-matched sibling transplantation for high-risk acute myeloid leukemia in first complete remission: a prospective multicentre cohort study.HLA 单倍型相合移植可能比 HLA 匹配同胞移植在高危急性髓系白血病首次完全缓解后具有更好的移植物抗白血病效应：一项前瞻性多中心队列研究。

Leukemia. 2020 May;34(5):1433-1443. doi: 10.1038/s41375-019-0686-3. Epub 2019 Dec 12.

Post-remission treatment with allogeneic stem cell transplantation in patients aged 60 years and older with acute myeloid leukaemia: a time-dependent analysis.60岁及以上急性髓系白血病患者异基因干细胞移植缓解后治疗：一项时间依赖性分析

Lancet Haematol. 2015 Oct;2(10):e427-36. doi: 10.1016/S2352-3026(15)00148-9. Epub 2015 Sep 18.

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Pre-transplant disease burden rather than age or donor type was associated with survival of hematopoietic cell transplantation for elderly patients with acute myeloid leukemia.

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