Neary D, Snowden J S, Bowen D M, Sims N R, Mann D M, Yates P O, Davison A N
J Neurol Neurosurg Psychiatry. 1986 Feb;49(2):157-62. doi: 10.1136/jnnp.49.2.157.
Investigation by cerebral biopsy of patients with dementia associated with cerebral atrophy permits the examination of clinico-pathochemical relationships, and provides a means of distinguishing and classifying forms of cerebral atrophy. Benefits of the procedure must however be weighed against possible adverse effects of surgical intervention. The study examines the outcome following biopsy of 24 patients with presenile dementia. No major operative complications were encountered, and recovery was uneventful in all but a single patient. The relevance of the findings to the study of dementia by cerebral biopsy is discussed.
通过对脑萎缩相关痴呆患者进行脑活检，能够检查临床病理化学关系，并提供区分和分类脑萎缩形式的方法。然而，该操作的益处必须与手术干预可能产生的不良影响相权衡。本研究调查了24例早老性痴呆患者活检后的结果。未出现重大手术并发症，除1例患者外，其他患者恢复均顺利。文中讨论了这些发现与通过脑活检研究痴呆的相关性。
