Seltzer B, Sherwin I
Arch Neurol. 1983 Mar;40(3):143-6. doi: 10.1001/archneur.1983.04050030037006.
The prevalence of a number of clinical features occurring in patients with early- (before age 65) and late-onset primary degenerative dementia of the Alzheimer type (PDDAT) are compared. The data from a total of 65 patients demonstrated a greater prevalence of language disturbance, a disproportionate number of left-handers, and a much shorter relative survival time in the early-onset group. Taken together with other data, these findings indicate a degree of heterogeneity in the clinical features of patients with PDDAT and suggest a possible heightened selective vulnerability of the left hemisphere in early-onset cases. We interpret the data as raising the possibility that the current view of PDDAT as a unitary disorder may not be entirely valid.
比较了早发性（65岁之前）和晚发性阿尔茨海默型原发性退行性痴呆（PDDAT）患者出现的一些临床特征的患病率。总共65例患者的数据表明，早发性组中语言障碍的患病率更高、左撇子的比例失调且相对生存时间短得多。结合其他数据，这些发现表明PDDAT患者的临床特征存在一定程度的异质性，并提示早发性病例中左半球可能存在更高的选择性易损性。我们认为这些数据增加了一种可能性，即目前将PDDAT视为单一疾病的观点可能并不完全正确。
