Munsaf Amna, Ahmed Muhammad Naeem, Zafar Aroosa, Akram Bilal, Ibrahim Mahmoud A A
Department of Chemistry, The University of Azad Jammu & Kashmir Muzaffarabad 13100 Pakistan.
Department of Chemistry, Women University of Azad Jammu & Kashmir Bagh 12500 AJ&K Pakistan.
RSC Adv. 2024 Nov 6;14(46):34156-34164. doi: 10.1039/d4ra06435f. eCollection 2024 Oct 23.
Cefixime, an antibiotic with low solubility, stability, bioavailability and therapeutic effectiveness, needs to be administered in larger doses for effective treatment. This can lead to higher healthcare costs and increased risk of side effects, negatively affecting public health. Herein, we aim to develop a strategy to overcome the aforementioned limitations by stabilizing it using franklinite nanostructures. Franklinite nanostructures (ZnFeO) were synthesized a green method and subsequently used as a support to stabilize cefixime (Cef). The successful formation of ZnFeO nanostructures and subsequent loading of the drug was confirmed using various microscopic and spectroscopic analyses. Solubility measurements and dissolution tests for the franklinite stabilized cefixime (Cef-ZnFeO) indicated increased solubility, enhanced bioavailability and greater absorption under physiological conditions. Hemolytic assay affirmed the safety and efficacy of drug stabilized by franklinite. Biological assessment of Cef-ZnFeO revealed that it has strong antifungal, antioxidant and kinase inhibition potential as compared to its bare counterpart. These findings emphasize the potential of newly designed Cef-ZnFeO as a promising nanoformulation with enhanced solubility, efficacy, safety and biological activities.
头孢克肟是一种溶解度、稳定性、生物利用度和治疗效果较低的抗生素，需要大剂量给药才能有效治疗。这可能导致更高的医疗成本和副作用风险增加，对公众健康产生负面影响。在此，我们旨在开发一种策略，通过使用锌铁尖晶石纳米结构对其进行稳定化处理来克服上述局限性。采用绿色方法合成了锌铁尖晶石纳米结构（ZnFeO），随后将其用作载体来稳定头孢克肟（Cef）。使用各种显微镜和光谱分析证实了ZnFeO纳米结构的成功形成以及随后药物的负载。对锌铁尖晶石稳定化头孢克肟（Cef-ZnFeO）的溶解度测量和溶出试验表明，在生理条件下其溶解度增加、生物利用度提高且吸收增强。溶血试验证实了锌铁尖晶石稳定化药物的安全性和有效性。与未处理的头孢克肟相比，Cef-ZnFeO的生物学评估表明它具有很强的抗真菌、抗氧化和激酶抑制潜力。这些发现强调了新设计的Cef-ZnFeO作为一种具有增强溶解度、疗效、安全性和生物活性的有前景的纳米制剂的潜力。
