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铜催化的氮中心自由基的生成及其反应。

Copper-catalyzed generation of nitrogen-centered radicals and reactions thereof.

作者信息

Chemler Sherry R

机构信息

Chemistry Department, Natural Science Complex, State University of New York at Buffalo, Buffalo, New York 14260, United States of America.

出版信息

ARKIVOC. 2024;2024(2). doi: 10.24820/ark.5550190.p012.078. Epub 2023 Nov 3.

DOI:10.24820/ark.5550190.p012.078
PMID:39507303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11540424/
Abstract

Nitrogen-centered radicals are reactive intermediates that can function in the formation of new C-N bonds or enable the formation of other bonds through their ability to abstract hydrogen atoms to generate carbon radical intermediates. Methods for the generation of nitrogen-centered radicals have traditionally involved application of radical initiators and propagators such as peroxides, AIBN and tin hydrides. More recently, approaches to nitrogen-centered radicals involving copper catalysis have been developed. In the transformations summarized herein, the copper catalyst either oxidizes or reduces the nitrogen-centered radical precursor. Some of these methods have been developed as catalytic enantioselective using chiral copper complexes.

摘要

以氮为中心的自由基是活性中间体，它们可以在形成新的C-N键中发挥作用，或者通过其夺取氢原子以生成碳自由基中间体的能力来促进其他键的形成。传统上，生成以氮为中心的自由基的方法涉及应用自由基引发剂和传播剂，如过氧化物、偶氮二异丁腈和氢化锡。最近，已经开发出了涉及铜催化的生成以氮为中心的自由基的方法。在本文总结的转化反应中，铜催化剂要么氧化要么还原以氮为中心的自由基前体。其中一些方法已被开发为使用手性铜配合物的催化对映选择性方法。

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