Joshi Prajakta, Usova Svetlana, Jinnah Hyder A, Sedov Alexey, Gamaleya Anna, Shaikh Aasef G, Semenova Ulia, Tomskiy Alexey
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Int IEEE EMBS Conf Neural Eng. 2023 May 19;2023. doi: 10.1109/NER52421.2023.10123779.
Cervical dystonia (CD) is the third most common movement disorder affecting 1 million people worldwide. Proprioceptive modulation is the hallmark of contemporary therapies for dystonia, but the mechanism for this intervention is unclear. We studied proprioceptive influence on CD by measuring the spontaneous single-neuron responses and local field potentials (LFP) from the globus pallidus interna (GPi) in 17 CD patients (9 isolated CD and 8 with CD as a feature of generalized dystonia). The goal was to examine how high-frequency neck vibration, a putative modulator of neck proprioception changes pallidal physiology. We found that the neck vibration instantaneously alters the pallidal single neuron activity. We also found that neck vibration modulates pallido-cerebellar connectivity by changing alpha band in LFP recordings. The effects were more robust in those with isolated CD. The vibration also affects pallido-hippocampal connectivity by modulating theta-band power. These effects were more robust in CD with generalized dystonia. Vibration changed LFP only in select pallidal regions. Regions where LFP power was substantially modulated had a prominent proportion of burst subtypes of neurons, compared to pause or tonic subtypes. Such disparity in subtype was absent in regions where the LFP power was not modulated or subtly reduced with neck vibration. When changes in the theta, alpha and beta bands of the LFP recordings were compared against each other in response to vibration, high correlation was observed.
颈部肌张力障碍（CD）是全球第三常见的运动障碍，影响着100万人。本体感觉调制是当代肌张力障碍治疗的标志，但这种干预的机制尚不清楚。我们通过测量17例CD患者（9例孤立性CD和8例以CD为全身性肌张力障碍特征）内侧苍白球（GPi）的自发单神经元反应和局部场电位（LFP），研究了本体感觉对CD的影响。目的是研究高频颈部振动（一种假定的颈部本体感觉调节剂）如何改变苍白球生理。我们发现颈部振动能瞬间改变苍白球单神经元活动。我们还发现颈部振动通过改变LFP记录中的α波段来调节苍白球 - 小脑连接。这些效应在孤立性CD患者中更为明显。振动还通过调节θ波段功率影响苍白球 - 海马连接。这些效应在全身性肌张力障碍合并CD患者中更为明显。振动仅在特定的苍白球区域改变LFP。与暂停或紧张性亚型相比，LFP功率被显著调制的区域中，爆发性神经元亚型占比突出。在LFP功率未被调制或因颈部振动而轻微降低的区域，不存在这种亚型差异。当比较LFP记录中θ、α和β波段对振动的反应变化时，观察到高度相关性。
