Boukricha Noura, Bnouhanna Wadii, Rahmani Mounia, Benabdeljlil Maria, Aidi Saadia
Ibn Sina University Hospital Center, Neurology A and Neuropsychology department, Rabat, Morocco.
Radiol Case Rep. 2024 Oct 24;20(1):248-251. doi: 10.1016/j.radcr.2024.09.132. eCollection 2025 Jan.
Marchiafava-Bignami disease is a rare neurological condition characterized by necrosis and demyelination of the corpus callosum, typically associated with chronic alcoholism and/or malnutrition. The clinical manifestations of Marchiafava-Bignami disease are diverse and often nonspecific. Diagnosis of Marchiafava-Bignami disease relies on magnetic resonance imaging findings, which reveal significant and symmetrical involvement of the corpus callosum. We report the case of a 48-year-old man with chronic alcoholism who has been experiencing symptoms of confusion, stupor, difficulties in using and manipulating objects, and balance disorders for the past 10 days. Brain magnetic resonance imaging revealed diffuse and complete involvement of the corpus callosum, characteristic of a severe form of Marchiafava-Bignami disease.
马奇亚法瓦-比尼亚米病是一种罕见的神经系统疾病，其特征是胼胝体坏死和脱髓鞘，通常与慢性酒精中毒和/或营养不良有关。马奇亚法瓦-比尼亚米病的临床表现多样且往往不具特异性。该病的诊断依赖于磁共振成像结果，这些结果显示胼胝体有显著且对称的病变。我们报告一例48岁慢性酒精中毒男性病例，在过去10天里，他出现了意识模糊、昏迷、使用和操作物体困难以及平衡障碍等症状。脑部磁共振成像显示胼胝体弥漫性完全受累，这是严重形式的马奇亚法瓦-比尼亚米病的特征。
