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Optimizing endovascular thrombectomy timing and thrombolysis use for ischemic stroke: insights from the SELECT2 and TIMELESS trials.

作者信息

Nendumba Gauthier, Moury Julien, Van Nieuwenhove Michael, Robert Arnaud, Hauqiert Benedicte, Vornicu Ovidiu, Blackman Sydney, Perriens Emily, Ghorayeb Ryma, Belhoussine Drissi Sofia, El Nawar Patrick, Philippot Alexis, Dincq Anne-Sophie, Evrard Patrick, Bulpa Pierre, Michaux Isabelle, Honore Patrick M

机构信息

ICU, CHU UCL Godinne Namur, UCL Louvain Medical School, Yvoir, Belgium.

ICU and Anesthesiology Departments, CHU UCL Godinne Namur, UCL Louvain Medical School, Yvoir, Belgium.

出版信息

Ann Transl Med. 2024 Oct 20;12(5):100. doi: 10.21037/atm-24-64. Epub 2024 Aug 30.

DOI:10.21037/atm-24-64
PMID:39507459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11534760/
Abstract
摘要

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Optimizing endovascular thrombectomy timing and thrombolysis use for ischemic stroke: insights from the SELECT2 and TIMELESS trials.优化缺血性卒中血管内血栓切除术时机及溶栓治疗应用：来自SELECT2和TIMELESS试验的见解
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2
A randomized controlled trial to optimize patient's selection for endovascular treatment in acute ischemic stroke (SELECT2): Study protocol.一项旨在优化急性缺血性脑卒中血管内治疗患者选择的随机对照试验（SELECT2）：研究方案。
Int J Stroke. 2022 Jul;17(6):689-693. doi: 10.1177/17474930211035032. Epub 2021 Dec 15.
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Endovascular therapy including thrombectomy for acute ischemic stroke: A systematic review and meta-analysis with trial sequential analysis.急性缺血性卒中的血管内治疗包括血栓切除术：一项采用试验序贯分析的系统评价和荟萃分析
J Clin Neurosci. 2016 Jul;29:38-45. doi: 10.1016/j.jocn.2015.12.025. Epub 2016 Mar 2.
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Front Neurol. 2021 Dec 13;12:752698. doi: 10.3389/fneur.2021.752698. eCollection 2021.
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Endovascular thrombectomy with or without intravenous thrombolysis in large-vessel ischemic stroke: A non-inferiority meta-analysis of 6 randomised controlled trials.血管内血栓切除术联合或不联合静脉溶栓治疗大动脉闭塞性缺血性卒中的非劣效性Meta 分析：6 项随机对照试验的荟萃分析。
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In large acute ischemic stroke, adding endovascular thrombectomy to medical therapy improved function at 90 d.在大型急性缺血性卒中中，血管内血栓切除术联合药物治疗可改善 90d 时的功能。
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本文引用的文献

1
Outcomes of Bridging Intravenous Thrombolysis Versus Endovascular Therapy Alone in Late-Window Acute Ischemic Stroke.静脉溶栓桥接治疗与单纯血管内治疗对急性缺血性脑卒中晚期患者的疗效比较。
Stroke. 2024 Jul;55(7):1767-1775. doi: 10.1161/STROKEAHA.124.046495. Epub 2024 May 15.
2
Long-term results of mechanical thrombectomy for large ischaemic stroke.大型缺血性脑卒中机械取栓术的长期疗效
Lancet. 2024 Feb 24;403(10428):700-701. doi: 10.1016/S0140-6736(24)00158-2. Epub 2024 Feb 9.
3
Endovascular thrombectomy plus medical care versus medical care alone for large ischaemic stroke: 1-year outcomes of the SELECT2 trial.
血管内血栓切除术联合药物治疗与单纯药物治疗大面积缺血性脑卒中的 1 年疗效：SELECT2 试验的结果。
Lancet. 2024 Feb 24;403(10428):731-740. doi: 10.1016/S0140-6736(24)00050-3. Epub 2024 Feb 9.
4
Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection.发病 4.5 至 24 小时的脑卒中患者采用灌注成像选择使用替奈普酶溶栓治疗。
N Engl J Med. 2024 Feb 22;390(8):701-711. doi: 10.1056/NEJMoa2310392. Epub 2024 Feb 8.
5
Mechanical thrombectomy for AIS from large vessel occlusion - current trends and future perspectives.大动脉闭塞性急性缺血性卒中的机械取栓术——当前趋势与未来展望
Ann Med Surg (Lond). 2023 Oct 4;85(12):6021-6028. doi: 10.1097/MS9.0000000000001385. eCollection 2023 Dec.
6
Trial of Endovascular Thrombectomy for Large Ischemic Strokes.大型缺血性卒中血管内血栓切除术试验
N Engl J Med. 2023 Apr 6;388(14):1259-1271. doi: 10.1056/NEJMoa2214403. Epub 2023 Feb 10.
7
Two-Year Outcome after Endovascular Treatment for Acute Ischemic Stroke.急性缺血性脑卒中血管内治疗两年后的结果。
N Engl J Med. 2017 Apr 6;376(14):1341-1349. doi: 10.1056/NEJMoa1612136.
8
Safety and efficacy of thrombectomy in acute ischaemic stroke (REVASCAT): 1-year follow-up of a randomised open-label trial.急性缺血性脑卒中血管内取栓术的安全性和有效性（REVASCAT）：一项随机、开放标签试验的 1 年随访结果。
Lancet Neurol. 2017 May;16(5):369-376. doi: 10.1016/S1474-4422(17)30047-9. Epub 2017 Mar 16.
9
Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials.血管内血栓切除术治疗大动脉闭塞性缺血性卒中的Meta 分析：来自五项随机试验的个体患者数据汇总分析
Lancet. 2016 Apr 23;387(10029):1723-31. doi: 10.1016/S0140-6736(16)00163-X. Epub 2016 Feb 18.
10
Repairing the human brain after stroke. II. Restorative therapies.中风后修复人类大脑。II. 恢复性疗法。
Ann Neurol. 2008 May;63(5):549-60. doi: 10.1002/ana.21412.