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肺肠型腺癌伴胃转移:一例罕见病例报告及文献复习。

Lung enteric-type adenocarcinoma with gastric metastasis: a rare case report and literature review.

机构信息

Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China.

Department of Pathology, The First Hospital of Jilin University, Changchun, Jilin, China.

出版信息

Front Immunol. 2024 Oct 23;15:1486214. doi: 10.3389/fimmu.2024.1486214. eCollection 2024.

DOI:10.3389/fimmu.2024.1486214
PMID:39507527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11537902/
Abstract

Lung enteric-type adenocarcinoma (ETAC) is a rare subtype of non-small cell lung cancer (NSCLC), comprising approximately 0.6% of all primary lung adenocarcinomas. It is characterized by a tendency for early metastasis and a prognosis comparable to that of common lung adenocarcinoma. This case report described a patient with lung-ETAC who developed gastric metastasis. The patient underwent treatment with chemotherapy and a PD-1 inhibitor, resulting in disease remission with a progression-free survival (PFS) of 8 months. The follow-up time was 13 months. This case report was aimed to enhance understanding of the biological behavior of this rare tumor and provide insights into potential future treatment strategies.

摘要

肺肠型腺癌(ETAC)是一种罕见的非小细胞肺癌(NSCLC)亚型,约占所有原发性肺腺癌的 0.6%。它的特点是早期转移倾向和预后与常见的肺腺癌相当。本病例报告描述了一例肺 ETAC 患者发生胃转移。该患者接受了化疗和 PD-1 抑制剂治疗,疾病缓解,无进展生存期(PFS)为 8 个月。随访时间为 13 个月。本病例报告旨在增强对这种罕见肿瘤的生物学行为的理解,并为潜在的未来治疗策略提供思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92c4/11537902/f54f7208d0b5/fimmu-15-1486214-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92c4/11537902/ce3a66449111/fimmu-15-1486214-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92c4/11537902/f54f7208d0b5/fimmu-15-1486214-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92c4/11537902/ce3a66449111/fimmu-15-1486214-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92c4/11537902/f54f7208d0b5/fimmu-15-1486214-g002.jpg

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Front Immunol. 2024 Jan 25;14:1266304. doi: 10.3389/fimmu.2023.1266304. eCollection 2023.
3
Gefitinib, an effective treatment option for patients with pulmonary enteric adenocarcinoma harboring compound EGFR L858R and A871G mutation.
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Invest New Drugs. 2023 Dec;41(6):787-790. doi: 10.1007/s10637-023-01401-3. Epub 2023 Oct 13.
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Frequent nuclear β-catenin expression in pulmonary enteric-type adenocarcinoma according to the current World Health Organization criteria.根据现行世界卫生组织标准,肺肠型腺癌中经常出现核β-连环蛋白表达。
Virchows Arch. 2023 Nov;483(5):699-703. doi: 10.1007/s00428-023-03657-9. Epub 2023 Sep 23.
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